Several studies have demonstrated the influence of religiosity and spirituality (R/S) on patients with chronic diseases. However, few studies have explored the influence of R/S on autoimmune/non-autoimmune rheumatic diseases. We conducted a systematic review of the literature on the impact of religiosity and spirituality (R/S) on the health of patients with (autoimmune and non-autoimmune) rheumatic diseases. Systematic review of the literature according to the PRISMA protocol. Articles published between January 1912 and September 2024 in the Virtual Health Library (VHL), PubMed, Web of Science, Cochrane Library, Scopus, and PsychInfo databases were included. Few studies have explored the influence of R/S on non-autoimmune rheumatic diseases. Most studies have evaluated the impact of R/S on central sensitization pain syndromes, such as fibromyalgia, and degenerative diseases, such as osteoarthritis. Only two studies have been conducted in patients with autoimmune rheumatic diseases, rheumatoid arthritis, and idiopathic inflammatory myopathies. Among the 1614 articles found, 17 met the eligibility criteria. In the quality analysis of the studies, 76.5% were classified as "good." The findings were then divided into "psychological and physical impacts of R/S in patients with autoimmune rheumatic diseases" and "psychological and physical impacts of R/S in patients with non-autoimmune rheumatic diseases". The literature demonstrates the impact of R/S on improving quality of life, especially on lower pain scores, reducing stress, and improving mood and life satisfaction. This evidence is the most robust for non-autoimmune rheumatic diseases. The effects of R/S on non-psychological aspects are uncertain. Additionally, studies have small samples, and most are not longitudinal. Therefore, longitudinal studies that consider differences such as the type of religion, standardization of R/S level mapping methods, and larger samples are necessary.
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http://dx.doi.org/10.1007/s10943-025-02287-6 | DOI Listing |
Front Immunol
March 2025
Rheumatology Unit, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint pain, swelling, and stiffness, affecting approximately 1% of the adult population. Tocilizumab (TCZ), a monoclonal antibody targeting the IL-6 receptor, has emerged as an effective treatment for RA. This narrative review provides an update on TCZ's efficacy and safety based on data from randomized controlled trials (RCTs) and real-world evidence (RWE).
View Article and Find Full Text PDFSheng Li Xue Bao
February 2025
Center for Translational Medicine Research on Sensory-Motor Diseases, Yan'an University, Yan'an 716000, China.
Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by synovitis and bone destruction. Its clinical characteristics are mainly joint pain, swelling, stiffness and joint deformity. Due to the poor efficacy of both drug and non-drug therapies, RA can significantly impact patients' quality of life and increase personal and socioeconomic burdens.
View Article and Find Full Text PDFMycoses
March 2025
Faculdade de Ciências da Saúde (FCS), Rodovia Dourados/Itahum, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
TNF-α inhibitors, including infliximab, adalimumab and etanercept, are used to treat various inflammatory diseases, such as arthritis, psoriasis and ankylosing spondylitis. However, these treatments may predispose patients to fungal infections, including histoplasmosis, candidiasis and aspergillosis. In this study, we systematically reviewed case reports to critically examine the correlations between anti-TNF-α therapies and the occurrence of invasive and superficial fungal infections.
View Article and Find Full Text PDFBMC Musculoskelet Disord
March 2025
Department of Orthopedic, General Hospital of Ningxia Medical University, 804 Shengli South Street, Yinchuan, Ningxia, 750004, China.
Objective: This meta-analysis evaluates the efficacy and safety of various topical dosage forms of diclofenac (gel, solution, and patch) for the treatment of knee osteoarthritis.
Methods: A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials evaluating topical diclofenac formulations in knee osteoarthritis patients. Data on pain relief, functional outcomes, and adverse events were extracted.
BMC Public Health
March 2025
School of Basic Medical Sciences of Zhejiang, Chinese Medical University, Binwen Road, Binjiang District, Hangzhou, China.
Objectives: This systematic review and meta-analysis aimed to investigate the association between vaccinations and the risk of rheumatoid arthritis (RA), specifically addressing concerns about a potential increased risk among vaccinated individuals.
Methods: A systematic search for cohort studies and case-control studies examining the association between vaccinations and RA was conducted using Medical Subject Headings and relevant keywords across PubMed, EMBASE, and Cochrane Library databases from inception to September 2024. The risk of bias of included studies was assessed using the Newcastle-Ottawa Scale.
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