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A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments.
Elife
March 2025
Machine Learning Core, National Institute of Mental Health, Bethesda, United States.
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce the detection of effects because they condense signals into summary measures, and discard trial-level information by averaging . We propose a novel photometry statistical framework based on functional linear mixed modeling, which enables hypothesis testing of variable effects at , and uses trial-level signals without averaging. This makes it possible to compare the timing and magnitude of signals across conditions while accounting for between-animal differences.
View Article and Find Full Text PDFSpinal Osteotomies for Cervicothoracic Sagittal Imbalance Correction: A Systematic Review and Meta-Analysis.
Global Spine J
March 2025
Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA.
Study DesignSystematic Review.ObjectivesCervicothoracic junction (CTJ) deformities, particularly kyphosis, significantly impact patients' quality of life, causing pain, dysphagia, and inability to maintain horizontal gaze. Various surgical osteotomy techniques are available to correct CTJ kyphosis, but their relative effectiveness and associated complications remain unclear.
View Article and Find Full Text PDFNew Insights into the Hydrogen Evolution Mechanism near the Ni/YSZ Triple Phase Boundary during Steam Electrolysis: A Patterned Model Electrode Study.
ACS Electrochem
March 2025
Institute of Physical Chemistry, University of Innsbruck, Innrain 52c, A-6020 Innsbruck, Austria.
Solid oxide cell technologies play a crucial role in climate change mitigation by enabling the reversible storage of renewable energy. Understanding the electrochemical high-temperature reaction mechanisms and the catalytic role of the electrode and electrolyte materials is essential for advancing power-to-H technologies. Despite its significance, limited spectroscopic research focusing on nickel and yttria-stabilized zirconia (Ni/YSZ) is available.
View Article and Find Full Text PDFTaiChi-MSS protocol: enhancing cognitive and brain function in MCI patients through Tai Chi exercise combined with multisensory stimulation.
Front Aging Neurosci
February 2025
School of Wushu, Shanghai University of Sport, Shanghai, China.
Background: The aging population in China is confronted with considerable challenges, with 14.71% of elderly individuals affected by mild cognitive impairment (MCI). The practice of Tai Chi has been demonstrated to enhance cognitive function, while sensory stimulation has been shown to facilitate neural activity.
View Article and Find Full Text PDFSpectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism.
Sovrem Tekhnologii Med
March 2025
Junior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.
Unlabelled: is to study the interaction of methylene blue (MB) with NADH, FADH coenzymes and lactate, and to evaluate a long-term effect of its intravenous or oral introduction on tumor metabolism .
Materials And Methods: The MB interaction with NADH, FADH coenzymes and lactate was studied using absorption spectrophotometry. A long-term effect of MB on tumor metabolism was investigated on a mice model of Ehrlich carcinoma.
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