Background: The inclusion of the colon as part of intestinal and multivisceral allografts has increased in the last decade.
Methods: We describe for the first time in the literature a full colon transplantation as a part of a visceral allograft. The new approach involves modifications of the procurement technique with preservation of all three visceral aortic branches and incorporation of the descending and sigmoid colon as a part of the allograft.
Result: Seventeen months after transplantation, the patient is off any parenteral nutritional support, on full oral nutrition without the need for a single antidiarrheal agent.
Conclusion: The introduction of this novel technique could open new opportunities for hindgut reconstruction for patients requiring visceral transplantation, with potential increase in allograft absorptive capacity and improvement in quality of life.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889015 | PMC |
http://dx.doi.org/10.1007/s10151-025-03115-5 | DOI Listing |
J Am Chem Soc
March 2025
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States.
Colonic mucus forms a first line of defense against bacterial invasion while providing nutrition to support coinhabiting microbes in the gut. Mucus is composed of polymeric networks of mucin proteins, which are heavily modified post-translationally. The full compendium of enzymes responsible for these modifications and their roles in health and disease remain incompletely understood.
View Article and Find Full Text PDFJ Crohns Colitis
March 2025
Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.
World J Gastroenterol
March 2025
Department of Gastroenterology, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, Shanxi Province, China.
Background: Ulcerative colitis (UC), a chronic and challenging condition, necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications. Traditional Chinese medicine (TCM), known for its multi-stage and multi-targeted approach, has a long history in treating gastrointestinal diseases and offering a promising alternative UC treatment. (), a commonly used remedy for UC in TCM, exemplifies this potential, although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated, highlighting the need for further research to unlock its full potential as a treatment option.
View Article and Find Full Text PDFTech Coloproctol
March 2025
Gastrointestinal Rehabilitation and Transplant Center - GIRTC, Starzl Transplantation Institute, Pittsburgh, PA, USA.
Background: The inclusion of the colon as part of intestinal and multivisceral allografts has increased in the last decade.
Methods: We describe for the first time in the literature a full colon transplantation as a part of a visceral allograft. The new approach involves modifications of the procurement technique with preservation of all three visceral aortic branches and incorporation of the descending and sigmoid colon as a part of the allograft.
Int J Emerg Med
March 2025
Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Introduction: Ogilvie's Syndrome (OS) is a rare but serious functional disorder characterized by dilatation of the colon, typically affecting the cecum and right colon, in the absence of any mechanical obstruction.
Case Presentation: We present an unusual case of Ogilvie's Syndrome in a 67-year-old female patient following elective dynamic hip screw surgery. She presented with gradual abdominal distention, as well as gas and stool retention.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!