Purpose: Currently, free-flap surgery with double innervation is considered a reliable and effective treatment in case of long standing facial paralysis. This study aimed to provide a current review of the literature (the "current state of the art") on lower third of the facial reanimation in restoring the voluntary and spontaneous smile in adult population using dual innervation free flap surgery.
Methods: We conducted a comprehensive literature review of all relevant papers by searching the electronic databases MEDLINE, Embase, Scopus, and the Cochrane Library.
Results: We included 12 retrospective studies involving 147 patients, five of which used the latissimus dorsi double innervation technique (42 patients) and seven of which investigated double innervation with a gracilis free flap (105 patients). In this review, we summarised the available data on smile recovery after free flap double innervation surgery. In half of the included studies, smiling was completely recovered.
Conclusions: Our study confirms that free flap surgery with dual innervation for long-term paralysis of the lower third of the face can guarantee comparable results using latissimus dorsi or gracilis free flaps. The best option depends on the case, taking into account the surgeon's skills and experience, as well as the patient's wishes and expectations.
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http://dx.doi.org/10.1007/s00405-025-09287-y | DOI Listing |
Neurogastroenterol Motil
March 2025
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
Backgrounds And Aims: Achalasia is an acquired esophageal neurodegenerative disorder, characterized by selective loss of inhibitory neurons in the myenteric plexus of the lower esophageal sphincter (LES). The Enteric neural precursor cell (ENPC) is essential in maintaining neurogenesis, but its role in achalasia pathogenesis is unknown. This study aimed to explore the neurogenesis status in the LES among achalasia patients.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
March 2025
Division of Maxillo-Facial Surgery, Department of Medicine, Surgery and Dentistry, ASST Santi Paolo e Carlo Hospital, University of Milan, Milan, Italy.
Purpose: Currently, free-flap surgery with double innervation is considered a reliable and effective treatment in case of long standing facial paralysis. This study aimed to provide a current review of the literature (the "current state of the art") on lower third of the facial reanimation in restoring the voluntary and spontaneous smile in adult population using dual innervation free flap surgery.
Methods: We conducted a comprehensive literature review of all relevant papers by searching the electronic databases MEDLINE, Embase, Scopus, and the Cochrane Library.
Brain
March 2025
Univ Lyon, Lyon Neuroscience Research Center (CRNL), CNRS UMR 5292, INSERM U1028, F- 69675 Bron, France.
Impulse control disorders (ICDs) are frequent and particularly distressing neuropsychiatric symptoms in patients with Parkinson's disease (PD) which are related to impaired behavioural inhibition. Multiple PET imaging studies indicate that striatal dopaminergic abnormalities contribute to hyperdopaminergic functioning in PD patients with ICD (PDICD+) and to the dysregulation of the limbic fronto-striatal networks which are critical for reward-related decision impulsivity. However, the serotonergic system is central to response inhibition and plays a critical role in neuropsychiatric symptoms in PD, but its role remains undetermined in PDICD.
View Article and Find Full Text PDFObjective: Skin nerve fiber deposition of proteins can be strongly associated with neurodegenerative diseases, such as phosphorylated α-synuclein (p-SN) in synucleinopathies. Little is known about other neurodegenerative proteins, such as tau or β-amyloid, in skin nerve fibers of patients with Alzheimer's disease (AD) and their link to underlying neurodegeneration. We therefore aimed for describing the presence and distribution of these proteins in the skin of patients with AD and non-AD controls.
View Article and Find Full Text PDFEur Heart J
February 2025
Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Background And Aims: Vagal parasympathetic dysfunction is strongly associated with impaired exercise tolerance, indicating that coordinated autonomic control is essential for optimizing exercise performance. This study tested the hypothesis that autonomic neuromodulation by non-invasive transcutaneous vagus nerve stimulation (tVNS) can improve exercise capacity in humans.
Methods: This single-centre, randomized, double-blind, sham-controlled, crossover trial in 28 healthy volunteers evaluated the effect of bilateral transcutaneous stimulation of vagal auricular innervation, applied for 30 min daily for 7 days, on measures of cardiorespiratory fitness (peak oxygen consumption (VO2peak)) during progressive exercise to exhaustion.
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