This perspective examines the impact of Social Determinants of Health (SDoH) on biological age-related decline and Alzheimer's Disease and Related Dementias (ADRD) biomarker trajectories in U.S. Latino populations, emphasizing the need for comprehensive multilevel research frameworks tailored to the community. We discuss the prevailing SDoH among U.S. Latino communities, including economic, educational, and healthcare access inequities that heighten health risks. Subsequently, we examine the pronounced differences in ADRD prevalence and biomarker trajectories among Latinos, suggesting that the interplay between SDoH and biological markers contributes to ADRD risk and progression. Our perspective reflects on the existing research landscape, noting a substantial gap in studies extending beyond identifying and understanding disparities in ADRD, to research incorporating biomarkers and developing actionable interventions to address broader SDoH. This shift is essential for creating a more holistic approach to ADRD research and devising truly effective strategies to mitigate ADRD disparities and improve brain health for older U.S. Latinos.
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