Ultra-high field magnetic resonance imaging (MRI) offers significant advantages in terms of signal-to-noise ratio and spatial resolution. In this study, we detail the development of a multi-channel home-built MRI console operating at 14 T. We propose a hybrid analog-digital framework that shifts high-frequency radio frequency transmission and reception issues to lower frequencies, utilizing software-defined radio technology to process these low-frequency signals. Digital pre-emphasis is used in gradient calculations to counteract the effects of eddy currents during gradient switching. Our console can transmit and receive at center frequencies up to 600 MHz. The pulse programmer module achieves a timing resolution of 20 ns, while the transmitter can independently generate waveforms with varying amplitude, frequency, phase, and envelope. The receiver's dual-stage gain control provides 63 dB of adjustable range, optimizing the magnetic resonance (MR) signal's dynamic range. After frequency conversion, the MR signals are digitized with 16-bit resolution and 100 MHz sampling rate. High-resolution water phantom images are acquired on the 14 T Bruker Ascend 600 nuclear magnetic resonance magnet, demonstrating its potential for clinical research and application.
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http://dx.doi.org/10.1063/5.0239183 | DOI Listing |
JAMA Netw Open
March 2025
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Importance: Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.
Objective: To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in later life.
Aging Dis
March 2025
Department of Radiology, Peking University Third Hospital, Beijing, China.
Neurochemical imbalance is a contributing factor to neurological symptoms in multiple sclerosis (MS). The matured myelin sheath is crucial for substance transportation within the extracellular space (ECS) and for maintaining local homeostasis. Therefore, we hypothesize that disturbed ECS transportation following demyelinating lesions might lead to neurochemical imbalance in MS.
View Article and Find Full Text PDFAddict Biol
March 2025
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Castellón, Spain.
Repetitive drug use results in enduring structural and functional changes in the brain. Addiction research has consistently revealed significant modifications in key brain networks related to reward, habit, salience, executive function, memory and self-regulation. Techniques like Voxel-based Morphometry have highlighted large-scale structural differences in grey matter across distinct groups.
View Article and Find Full Text PDFElife
March 2025
Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States.
Research on brain plasticity, particularly in the context of deafness, consistently emphasizes the reorganization of the auditory cortex. But to what extent do all individuals with deafness show the same level of reorganization? To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. Our findings demonstrate remarkable differentiation between individuals deriving from the absence of shared auditory experiences, resulting in heightened FC variability among deaf individuals, compared to more consistent FC in the hearing group.
View Article and Find Full Text PDFJ Magn Reson Imaging
March 2025
Department of Radiology, Central Hospital of Dalian University of Technology, Dalian, People's Republic of China.
Unlabelled: Four-dimensional flow cardiovascular magnetic resonance (4D Flow cardiac MRI) is an advanced non-invasive imaging technology, and its derived kinetic energy (KE) blood flow parameters have been confirmed as a potential biomarkers for assessing ventricular hemodynamics. This review synthesizes details on the methodology, clinical significance, and current status of studies focused on quantifying KE parameters of the ventricle using 4D Flow cardiac MRI, providing an objective foundation for further exploration of the value of KE in cardiac diseases.
Study Type: retrospective.
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