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Virulence factors, molecular characteristics, and resistance mechanisms of carbapenem-resistant Pseudomonas aeruginosa isolated from pediatric patients in Shanghai, China.
BMC Microbiol
March 2025
Department of Nosocomial Infection Control, The Clinical Laboratory, Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Background: The investigation into virulence factors, clinical and molecular characteristics, and resistance mechanisms of carbapenem-resistant Pseudomonas aeruginosa (CRPA) in pediatric populations is currently inadequate.
Purpose: This study aimed to investigate the virulence factors, clinical and molecular characteristics, and resistance mechanisms of 135 CRPA isolates in Shanghai, China.
Methods: Analysis of virulence-associated genes and multilocus sequence typing (MLST) provided epidemiological and molecular insights into the isolates.
INFECTIOUS ENTEROCOLITIS IN HEMATOPOIETIC CELL TRANSPLANT WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE.
Transplant Cell Ther
March 2025
Hematology Department, Hospital Universitari i Politècnic La Fe, València, Spain; Hematology Research Group, Institut d'Investigació Sanitària La Fe, València, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, Madrid, Spain; Medicine Department, Universitat de València, Spain.
Background: Despite the high incidence of diarrhea in hematopoietic cell transplant (HCT) recipients, data on infectious enterocolitis with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis remain limited.
Objectives: Evaluate the characteristics, incidence, risk factors, and impact on outcomes of infectious enterocolitis in patients with hematologic malignancies undergoing HCT from matched sibling, matched unrelated, and haploidentical donors using PTCy as GVHD prophylaxis.
Study Design: Retrospective analysis of infectious enterocolitis episodes in 399 patients undergoing HCT at a single institution.
Background: The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.
Methods: In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed.
Mobile genetic elements encoding antibiotic resistance genes and virulence genes in : important pathways for the acquisition of virulence and resistance.
Front Microbiol
February 2025
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
is an opportunistic pathogen primarily associated with nosocomial infections, characterized by a propensity for multi-drug resistance and the potential evolution into hypervirulent strains. Based on its phenotypic and genotypic characteristics, can be classified into two types: classical (cKP) and hypervirulent (hvKP). The spread of mobile genetic elements (MGEs) in has led to the emergence of carbapenem-resistant (CRKP) and carbapenem-resistant hypervirulent (CR-hvKP).
View Article and Find Full Text PDFGenomic and phenotypic characterisation of isolates from canine otitis externa reveals high-risk sequence types identical to those found in human nosocomial infections.
Front Microbiol
February 2025
School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
Introduction: Canine otitis externa (OE) is a frequently-diagnosed condition in veterinary practices worldwide. is commonly associated with chronic and recalcitrant canine OE, but studies with detailed genomic and phenotypic characterisation of clinical isolates are lacking.
Methods: canine OE isolates ( = 253) were collected from different geographical locations in Europe and characterised with respect to antimicrobial resistance and biofilm formation.
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