Vinyl sulfides and their sulfones act as very important building blocks in organic synthesis. Further they are prevalent in bioactive natural and unnatural products and exhibit diverse bioactivities. Here in we report a Z-enoate assisted Meyer-Schuster rearrangement approach for the rapid generation of 1,4-ketoester based vinyl sulfides. The thiols were employed as nucleophiles during this versatile transformation the propargylic alcohols. The process exhibited broader scope for thiols (aryl and alkyl), and propargylic alcohols. Further these vinyl sulfides were efficiently converted into the corresponding vinyl sulfones by employing a Mo-based oxidizing agent. Sodium borohydride reduction of the 1,4-ketoester based vinyl sulfides directly gave the butyrolactones having the vinyl sulfide unit. The phenols, alcohols and amines were found to be inefficient as nucleophiles to give the corresponding vinyl ethers.
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Vinyl sulfides and their sulfones act as very important building blocks in organic synthesis. Further they are prevalent in bioactive natural and unnatural products and exhibit diverse bioactivities. Here in we report a Z-enoate assisted Meyer-Schuster rearrangement approach for the rapid generation of 1,4-ketoester based vinyl sulfides.
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A highly enantioselective electrophilic selenylation/semipinacol rearrangement of allenols has been developed, which is enabled by the cooperative catalysis of a chiral sulfide and an achiral sulfonic acid. The designed and synthesized chiral sulfide catalyst and selenylating reagent play a crucial role in enhancing both enantioselectivity and reactivity. This approach exhibits excellent regio-, chemo-, and enantioselectivity, providing access to diverse enantioenriched cyclopentanones featuring an arylselenovinyl-substituted quaternary carbon stereocenter.
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Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu 610041, China.
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