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Strategies to Enhance Protein Delivery. | LitMetric

Strategies to Enhance Protein Delivery.

Langmuir

Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States.

Published: March 2025

Therapeutic proteins play a crucial role in modern healthcare. However, the rapid clearance of proteins in the circulation system poses a significant threat to their therapeutic efficacy. The generation of anti-drug antibodies expedites drug clearance, resulting in another challenge to overcome in protein delivery. Several methods to increase the circulation half-lives of these proteins and to minimize their immunogenicity have been developed. This Review discusses the causes of protein clearance in the body, evaluates the FDA-approved strategies to prolong protein circulation, and highlights recent progress in the field. Additionally, the strengths and drawbacks of these methods and our perspectives for advancing protein delivery are provided.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.4c04636DOI Listing

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