Background: Social determinants of health (SDOH) domains outlined by the American Cancer Society may provide a comprehensive understanding of the factors that influence adherence to cervical cancer screening recommendations. However, the relationship between the domains and screening adherence has not been previously examined.
Objective: This study aims to explore the relationship between SDOH domains and adherence to cervical cancer screening guidelines among US women aged 21 to 64 years, using data from the Health Information National Trends Survey cycle 6 (n = 6252).
Methods: Weighted multivariate logistic regressions, incorporating jackknife replicate weights, were conducted using all the domains of SDOH.
Results: The sample includes 2037 respondents. An estimated 74.3% (61 318 532/82 499 191; 95% confidence interval [CI], 70.9%-78.0%) of the weighted adult population of women aged 21 to 64 years in the United States were adherent with the US Preventive Task Force screening recommendations. The mean age of the adherent and nonadherent populations was 43.6 years (95% CI, 42.9-44.34 years) and 42.5 years (95% CI, 40.5-44.5 years), respectively. Adherence to cervical cancer screening guidelines was significantly associated with decreasing social isolation independent of ethnicity, body mass index, knowledge of cervical cancer, marital status, and urban-rural designation (odds ratio, 0.98; P = .009).
Conclusions: The screening rate is below the Healthy People 2030 target (79.2%). These findings underscore the importance of comprehensive approaches to address social isolation and its influence on screening behaviors.
Implications For Practice: Researchers and health practitioners should increase attention to and embrace the 6 foundational pillars of the Surgeon General's advisory framework to advance social connection in the United States.
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http://dx.doi.org/10.1097/NCC.0000000000001481 | DOI Listing |
Elife
March 2025
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.
View Article and Find Full Text PDFIran J Pharm Res
November 2024
Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Background: Invasive cervical cancer is recognized as the second most common malignancy in women after breast cancer.
Objectives: This study investigates, for the first time, the effect of gold nanoparticle-doped graphene oxide (GO) nanosheets on the human epithelial carcinoma (HeLa) cell line in the presence of heliox cold plasma.
Methods: Graphene oxide nanosheets were synthesized using the Hummer method and then doped with gold nanoparticles.
Front Oncol
February 2025
Department of Medical Oncology, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), and CIBERONC, Madrid, Spain.
Background: Immunotherapy has gained momentum with the discovery of novel antibodies targeting immunosuppressive proteins. HLA-E, a non-classical major histocompatibility complex class I (MHC-I) protein, exhibits immunosuppressive properties, potentially influencing tumor immune evasion mechanisms. The association between Human Leukocyte Antigen E (HLA-E) expression and outcomes in solid tumors remains unclear.
View Article and Find Full Text PDFPatient Prefer Adherence
March 2025
Department of Gynecological Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
Purpose: This quantitative study aimed to determine whether the quality of discharge teaching, anxiety, depression, and various demographic and disease-related factors predict discharge readiness among cervical cancer surgical patients in Western Region of China.
Methods: From November 2023 to May 2024, a convenience sampling method was employed to administer a questionnaire to cervical cancer surgery patients at a tertiary Grade A specialized hospital in Xinjiang. The survey included a patient general information questionnaire, the Quality of Discharge Teaching Scale (QDTS), the Generalized Anxiety Disorder 7-item Scale (GAD-7), a questionnaire assessing the readiness for discharge of gynecological malignant tumor surgery patients under the enhanced recovery after surgery (ERAS) model, and the Patient Health Questionnaire-9 (PHQ-9).
Int J Gen Med
March 2025
Shenzhen Polytechnic University, Shenzhen, 518055, People's Republic of China.
Objective: To investigate immune cell crisis and excess histopathological features during the development and progression of infection in the gastric mucosa.
Methods: One thousand two hundred and seventy-six cases of infection were examined by endoscopic biopsy and endoscopic submucosal dissection (ESD) resection. The relationship between epithelial cells and immune cells and the pathological features of immune cell dysfunction and excess tissue were observed.
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