Objective: Many studies focus on impediments to healthy ageing, but few examine factors leading to healthy ageing. Whilst many older First Nations people are ageing well, few studies have examined this issue in First Nations people. This study examined indicators associated with healthy ageing in the Torres Strait region of Queensland, Australia.
Methods: Data from a Torres Strait Dementia Prevalence Study (2015-2018) were used to explore indicators of healthy ageing in 249 participants. A specific Torres Strait Healthy Ageing Index was created, based on 10 indicators from the dataset. One point was assigned for each indicator, with higher scores representing healthier ageing. This Index was then used to assess healthy ageing in a subset of participants aged 70 years and older.
Results: Healthy ageing scores were higher in younger people. However, among 80 people aged ≥ 70 years, many were ageing well according to the healthy ageing index, with 44% scoring 7-8 and 28% scoring 9-10. Age-adjusted analyses identified that more education, lack of vascular risk factors, good medication prescribing patterns, absence of stroke and geographic location were all associated with a higher healthy ageing index.
Conclusions: Our study suggested that many older First Nations residents of the Torres Strait region were ageing in a healthy way, based on the indicators available. The results showed both predictable and unexpected associations with healthy ageing. Stroke prevention stood out as a key priority. These results highlight the need for prospective population studies to better understand, promote and celebrate healthy ageing in this population.
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http://dx.doi.org/10.1111/ajr.70020 | DOI Listing |
Sci Adv
March 2025
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored.
View Article and Find Full Text PDFCereb Cortex
March 2025
Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
This study investigates the relationship between resting-state functional magnetic resonance imaging (rs-fMRI) topological properties and synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) synaptic density (SD) in late-life depression (LLD). 18 LLD patients and 33 healthy controls underwent rs-fMRI, 3D T1-weighted MRI, and 11C-UCB-J PET scans to assess SD. The rs-fMRI data were utilized to construct weighted networks for calculating four global topological metrics, including clustering coefficient, characteristic path length, global efficiency, and small-worldness, and six nodal metrics, including nodal clustering coefficient, nodal characteristic path length, nodal degree, nodal strength, local efficiency, and betweenness centrality.
View Article and Find Full Text PDFGeroscience
March 2025
Dept. Of Bioinformatics, Semmelweis University, 1094, Budapest, Hungary.
The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short and long sleep durations impact stroke incidence and mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar up to November 1, 2024, to identify cohort studies evaluating sleep duration and stroke outcomes.
View Article and Find Full Text PDFGeroscience
March 2025
Doctoral College, Health Sciences Program, Semmelweis University, Budapest, Hungary.
Sleep duration is a crucial factor influencing health outcomes, yet its relationship with mortality remains debated. In this meta-analysis, we aimed to investigate the association between short and long sleep duration and all-cause mortality in adults, including sex-specific differences. A systematic search was performed in multiple databases, including PubMed, Cochrane Central, and Web of Science, up to October 2024.
View Article and Find Full Text PDFJAMA Netw Open
March 2025
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Importance: Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.
Objective: To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in later life.
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