Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.20344/amp.22484 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genotype, Ethnicity, and Drug-Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin-I Story.
CPT Pharmacometrics Syst Pharmacol
March 2025
Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.
Coproporphyrin-I (CP-I) is a selective endogenous biomarker of organic anion-transporting polypeptide (OATP)1B. Multiple CP-I PBPK models with differing input parameters have been reported so far. This study proposed a harmonized CP-I PBPK model and evaluated its ability to predict the effect of ethnicity, SLCO1B1 genotype c.
View Article and Find Full Text PDFGram-positive infections in special populations. Expert view on the role of dalbavancin.
Expert Rev Anti Infect Ther
March 2025
Head of the Infectious Diseases/Microbiology Department, Clínica Universidad de Navarra, Spain.
Introduction: This review considers special populations as those patients for whom Gram-positive infections are particularly challenging to treat. We examine the potential benefits of dalbavancin in these patients.
Areas Covered: We focus on patients with renal impairment, hepatic failure or obesity, and, also, pediatric patients, elderly patients and socially vulnerable individuals.
Efficacy and safety of self-retaining double-needle barb suture in transabdominal path robot-assisted laparoscopic partial nephrectomy for T1 renal cancer.
BMC Cancer
March 2025
Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, China.
Objectives: This study evaluated the safety and efficacy of self-retaining barbed double-layer sutures (SRBDS) used for wound sutures in stage T1 renal cancer undergoing peritoneal robot-assisted laparoscopic partial renal resection.
Methods: A total of 50 patients undergoing robot-assisted laparoscopic partial nephrectomy (RAPN) for localized renal tumors (< 7 cm) in Zhejiang Provincial People's Hospital from January 2021 to January 2022 were selected. The experimental-group and the control-group randomly included 25 patients, respectively.
Background Renal artery stenosis (RAS) is characterized by reduced renal perfusion, activating the renin-angiotensin-aldosterone system (RAAS), which can lead to secondary hypertension, ischemic nephropathy, and cardiac destabilization syndrome. These conditions have significant healthcare implications. Renovascular hypertension (RVH) in RAS patients can be managed through medical therapy and revascularization, either endovascular or surgical.
View Article and Find Full Text PDFImpact of extended [Lu] Lu-PSMA-617 therapy on absorbed kidney dose and CKD-EPI values: how long can therapy be safely continued?
Eur J Nucl Med Mol Imaging
March 2025
Istanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul University, Fatih, İstanbul, 34093, Turkey.
Purpose: This study aimed to evaluate the personalized dosimetric approach by calculating the cumulative renal absorbed dose (cRD) and assessing its impact on renal functions in patients diagnosed with metastatic castration-resistant prostate cancer who underwent four or more cycles of [Lu] Lu-PSMA - 617 therapy.
Methods: The study included 110 patients who received ≥ 4 cycles of [Lu] Lu-PSMA - 617 therapy. Whole-body static and abdominal SPECT-CT imaging was performed at 4, 24, and 96 h post-administration.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!