The new HLA-DQB1*06:02:65 allele showed one synonymous nucleotide difference compared to the HLA-DQB1*06:02:01:01 allele in codon 591.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/tan.70111 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Is Childhood IgA Nephropathy Different From Adult IgA Nephropathy? A Narrative Review.
Can J Kidney Health Dis
March 2025
Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, AB, Canada.
Purpose Of The Review: Immunoglobulin A (IgA) nephropathy (IgAN) is the most common primary glomerular kidney disease. Children and adults are presumed to have the same disease and are treated similarly. However, there are differences between childhood IgAN and adult IgAN that may require unique treatment considerations, even after transition to adult nephrology services.
View Article and Find Full Text PDFImproved genetic screening with zygosity detection through multiplex high-resolution melting curve analysis and biochemical characterisation for G6PD deficiency.
Trop Med Int Health
March 2025
Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia (UTM), Johor Bahru, Malaysia.
Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is crucial for relapse malaria treatment using 8-aminoquinolines (primaquine and tafenoquine), which can trigger haemolytic anaemia in G6PD-deficient individuals. This is particularly important in regions where the prevalence of G6PD deficiency exceeds 3%-5%, including Southeast Asia and Thailand. While quantitative phenotypic tests can identify women with intermediate activity who may be at risk, they cannot unambiguously identify heterozygous females who require appropriate counselling.
View Article and Find Full Text PDFHighly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors.
Mol Oncol
March 2025
Center for Digital Services - Healthcare, Research & Development Group, Hitachi, Ltd., Tokyo, Japan.
Pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursor lesions. Detecting these precursors and monitoring their progression are crucial for early PDAC diagnosis. Digital PCR (dPCR) is a highly sensitive nucleic acid quantification technique and offers a cost-effective option for patient follow-up.
View Article and Find Full Text PDFGene-Lifestyle Interactions in Renal Dysfunction: Polygenic Risk Modulation via Plant-Based Diets, Coffee Intake, and Bioactive Compound Interactions.
Nutrients
March 2025
Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, 20 Hoseoro97bun-gil, BaeBang-Yup, Asan 41399, ChungNam-Do, Republic of Korea.
This study aimed to investigate genetic variants associated with the estimated glomerular filtration rate (eGFR) and their interactions with lifestyle factors and bioactive compounds in large hospital-based cohorts, assessing their impact on renal dysfunction risk. Participants were categorized into two groups based on eGFR: High-GFR (control; = 51,084) and Low-GFR (renal dysfunction; = 7617), using an eGFR threshold of 60 mL/min/1.73 m.
View Article and Find Full Text PDFGene-Diet Interactions in High-Density Lipoprotein Cholesterol-Related Polymorphisms and Cardiovascular Disease Risk: Insights from the Korean Genome and Epidemiology Study.
Nutrients
February 2025
Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea.
: Understanding gene-diet interactions is crucial for establishing dietary guidelines for cardiovascular diseases (CVD). This study analyzed the interaction between dietary intake and six genome-wide association study (GWAS)-identified single nucleotide polymorphisms (SNP) associated with high-density lipoprotein (HDL) cholesterol levels and their impact on CVD risk. : A total of 68,806 participants in the Korean Genome and Epidemiology Study (KoGES) were analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!