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Neuroprotective Effects of Metformin in Stroke Patients: A Systematic Review and Meta-analysis of Cohort Studies.
Clin Neuropharmacol
March 2025
Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Science, Fasa, Iran.
Objectives: People with diabetes are 1.5 times more likely to experience stroke than those without diabetes, underlining the urgent need to address this issue. Metformin is often the initial medication chosen to manage diabetes mellitus (DM).
View Article and Find Full Text PDFTransitioning to Intravenous Tenecteplase for the Treatment of Acute Ischemic Stroke.
JAMA Netw Open
March 2025
Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke.
JAMA Netw Open
March 2025
Department of Neurology, Dell Medical School, The University of Texas at Austin.
Importance: Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice.
Objective: To compare short-term effectiveness and safety outcomes for patients with ischemic stroke treated with intravenous tenecteplase vs alteplase.
Food Insecurity and Incident Cardiovascular Disease Among Black and White US Individuals, 2000-2020.
JAMA Cardiol
March 2025
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Importance: Food insecurity is associated with prevalent cardiovascular disease (CVD), but studies have been limited to cross-sectional data.
Objectives: To study whether food insecurity is associated with incident CVD and to determine whether this association varies by sex, education, or race.
Design, Setting, And Participants: This prospective cohort study was conducted among US adults without preexisting CVD participating in the CARDIA (Coronary Artery Risk Development in Young Adults) study from 2000 to August 31, 2020.
Collateral blood vessels in stroke and ischemic disease: Formation, physiology, rarefaction, remodeling.
J Cereb Blood Flow Metab
March 2025
Department of Cell Biology and Physiology, Curriculum in Neuroscience, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Collateral blood vessels are unique, naturally occurring endogenous bypass vessels that provide alternative pathways for oxygen delivery in obstructive arterial conditions and diseases. Surprisingly however, the capacity of the collateral circulation to provide protection varies greatly among individuals, resulting in a significant fraction having poor collateral circulation in their tissues. We recently reviewed evidence that the presence of naturally-occurring polymorphisms in genes that determine the number and diameter of collaterals that form during development (ie, genetic background), is a major contributor to this variation.
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