Thalidomide as Treatment of Lip's Pyogenic Granuloma.

Int Med Case Rep J

Department of Dermatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, People's Republic of China.

Published: March 2025

Pyogenic granuloma (PG) is a benign vascular tumor that can be challenging to treat, particularly in aesthetically sensitive areas. We report a case of a 32-year-old man with a PG on the upper lip that did not respond to conventional treatments, including glucocorticoid injections and long-pulse 1064 nm laser therapy. Due to aesthetic concerns and the lack of response to these treatments, the patient was administered oral thalidomide at a nightly dose of 75 mg for 5 months, which resulted in complete regression without recurrence over a 3-year follow-up. This case suggests thalidomide's potential as an effective alternative treatment for PG in sensitive areas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883175PMC
http://dx.doi.org/10.2147/IMCRJ.S511053DOI Listing

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