Inspired by biological sensors that characteristically adapt to varying stimulus ranges, efficiently detecting stimulus changes sooner than the absolute stimulus values, we propose a mechanosensing concept in which the resolution can be adapted by magnetic field () gating to detect small pressure-changes under a wide range of compressive stimuli. This is realized with resistive sensing by pillared -driven assemblies of soft ferromagnetic electrically conducting particles between planar electrodes under a voltage bias. By modulation of , the pillars respond with mechanically adaptable sensitivity. Higher enhances current resolution, while it increases scatter among repeating measurements due to increased magnetic structural jamming between colloids in their assembly. To manage the trade-off between electrical resolution and scatter, machine learning is introduced for searching optimum gatings, thus facilitating efficient pressure prediction. This approach suggests bioinspired pathways for developing adaptive stimulus-responsive mechanosensors, detecting subtle changes across varying stimuli levels with enhanced effectiveness through machine learning.
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http://dx.doi.org/10.1021/acsmaterialslett.4c02021 | DOI Listing |
JMIR Med Inform
March 2025
LynxCare Inc, Leuven, Belgium.
Background: Processing data from electronic health records (EHRs) to build research-grade databases is a lengthy and expensive process. Modern arthroplasty practice commonly uses multiple sites of care, including clinics and ambulatory care centers. However, most private data systems prevent obtaining usable insights for clinical practice.
View Article and Find Full Text PDFJMIR Res Protoc
March 2025
Institute for Data Science and Informatics, University of Missouri, Columbia, MO, United States.
Background: Amyotrophic lateral sclerosis (ALS) leads to rapid physiological and functional decline before causing untimely death. Current best-practice approaches to interdisciplinary care are unable to provide adequate monitoring of patients' health. Passive in-home sensor systems enable 24×7 health monitoring.
View Article and Find Full Text PDFJ Med Chem
March 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine; Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The anticancer agent irinotecan often induces severe delayed-onset diarrhea, inhibiting human carboxylesterase 2A (hCES2A) can significantly alleviate irinotecan-triggered gut toxicity (ITGT). This work presents an efficient workflow for design and developing novel efficacious hCES2A inhibitors. A well-training machine learning model identified as a lead compound, while compound was developed as a novel time-dependent hCES2A inhibitor (IC = 0.
View Article and Find Full Text PDFMol Inform
March 2025
Faculty of Information Technology, HUTECH University, Ho Chi Minh City, Vietnam.
Within a recent decade, graph neural network (GNN) has emerged as a powerful neural architecture for various graph-structured data modelling and task-driven representation learning problems. Recent studies have highlighted the remarkable capabilities of GNNs in handling complex graph representation learning tasks, achieving state-of-the-art results in node/graph classification, regression, and generation. However, most traditional GNN-based architectures like GCN and GraphSAGE still faced several challenges related to the capability of preserving the multi-scaled topological structures.
View Article and Find Full Text PDFJ AOAC Int
March 2025
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6 Canada.
Background: Plant-based milk alternatives (PBMA) are increasingly popular due to rising lactose intolerance and environmental concerns over traditional dairy products. However, limited efforts have been made to develop rapid authentication methods to verify their biological origin.
Objective: In this study, we developed a rapid, on-site analytical method for the authentication and identification of PBMA made by six different plant species utilizing a portable Raman spectrometer coupled with machine learning.
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