We describe the case of a 73-year-old man who had been followed up by our clinic for pulmonary hypertension and asthma. He was later hospitalized and found to have significant and persistent eosinophilia compatible with hypereosinophilic syndrome. Various other conditions such as drug reaction with eosinophilia and systemic symptoms (DRESS), malignancy, and eosinophilic granulomatosis with polyangiitis (EGPA) were considered but largely excluded after further investigation. He responded well to steroids and was transitioned to mepolizumab for long-term control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884384 | PMC |
| http://dx.doi.org/10.7759/cureus.78486 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Highlights from the plenary session: eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome.
Rheumatology (Oxford)
March 2025
Nephrology and Dialysis Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA) both present with hypereosinophilia and organ damage induced by eosinophils. EGPA is also characterized by vasculitis and is associated with ANCA. Yet, discriminating HES from EGPA may be difficult in clinical practice as biomarkers to reliably differentiate between HES and EGPA are still lacking.
View Article and Find Full Text PDFWe describe the case of a 73-year-old man who had been followed up by our clinic for pulmonary hypertension and asthma. He was later hospitalized and found to have significant and persistent eosinophilia compatible with hypereosinophilic syndrome. Various other conditions such as drug reaction with eosinophilia and systemic symptoms (DRESS), malignancy, and eosinophilic granulomatosis with polyangiitis (EGPA) were considered but largely excluded after further investigation.
View Article and Find Full Text PDFMore Than Just Stool: Hypereosinophilic Syndrome Presenting as Persistent Diarrhea in a Patient With Ulcerative Colitis.
J Brown Hosp Med
October 2024
Division of Hospital Medicine, Emory University School of Medicine, Atlanta, GA, USA.
We highlight a case of non-infectious diarrhea that progressed despite supportive care, prompting further workup. A 50-year-old man presented with 1 week of voluminous diarrhea, nausea, emesis, and abdominal pain. His history included ulcerative colitis, primary sclerosing cholangitis, treated via total colectomy with ileoanal pouch, treated disseminated complex, and international travel.
View Article and Find Full Text PDFEfficacy of anti-interleukin 5 therapy in hypereosinophilic syndrome: An updated systematic review and meta-analysis.
Allergy Asthma Proc
March 2025
From the Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan.
Hypereosinophilic syndromes (HES) are marked by persistent eosinophilia, absence of a primary cause, and evidence of eosinophil-mediated organ damage. HES presents a spectrum of clinical manifestations, with prognosis and treatment varying based on the subtype, including myeloid/lymphoid neoplasms and chronic eosinophilic leukemia, not otherwise specified. The primary treatment goal is to reduce eosinophil levels to prevent organ damage, typically by using glucocorticoids and immunosuppressive agents.
View Article and Find Full Text PDF[Eosinophilic Lung Diseases: Time Pressure in the Maze of Differential Diagnoses].
Praxis (Bern 1994)
January 2025
Klinik für Pneumologie, Universitätsspital Zürich.
We present a case with eosinophilic granulomatosis with polyangiitis (EGPA). We provide an overview of eosinophilic lung diseases and underline challenges in diagnosis and management of those diseases. Furthermore, we discuss the severity classification of EGPA and provide insight into the current treatment regimen.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!