A 38-year-old male with Gilbert syndrome presented with acute cholecystitis, jaundice, and elevated liver enzymes. This case highlights the importance of genetic testing for unexplained jaundice, avoiding misdiagnosis, and guiding personalized treatment for Gilbert syndrome.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882763 | PMC |
http://dx.doi.org/10.1002/ccr3.70290 | DOI Listing |
Background: Survival rates after a diagnosis of cancer are improving. Poorly managed gastrointestinal (GI) side effects can interfere with delivery of curative cancer treatment. Long-term physical side effects of cancer therapy impinge on quality of life in up to 25% of those treated for cancer, and GI side effects are the most common and troublesome.
View Article and Find Full Text PDFJ Zoo Wildl Med
March 2025
Northwest ZooPath, Monroe, WA 98272, USA.
Amyloidosis is the pathologic extracellular deposition of amyloid, a proteinaceous substance, in various tissues and organs. The most common form of amyloidosis in domestic animals is amyloid A amyloidosis, though amyloid light chain, amyloid β, and islet amyloid polypeptide amyloidosis have been documented. In reptiles, amyloidosis, or amyloid-like disorders, are considered rare.
View Article and Find Full Text PDFNPJ Drug Discov
March 2025
Department of Pediatrics, University of California, San Diego, La Jolla, CA USA.
Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space is also constrained by existing compound libraries and phenotypic assay conditions.
View Article and Find Full Text PDFClin Infect Dis
March 2025
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Introduction: Viral blips have been associated with larger reservoir size and slower decay. Earlier antiretroviral therapy (ART) initiation may decrease the risk of blips.
Methods: We analyzed participants from the U.
J Racial Ethn Health Disparities
March 2025
Tilman J. Fertitta Family College of Medicine, The University of Houston, 5055 Medical Circle, Houston, TX, USA.
Background: Due to limited research on Asian Americans and COVID-19, we investigated the perspectives of Vietnamese Americans regarding COVID-19 vaccine acceptance, trusted sources of information, and pandemic-related challenges.
Methods: Vietnamese American adult residents in Texas were recruited between September 2021 through March 2022 to complete the NIH CEAL Common Survey 2 electronically in English or Vietnamese, which contains 23 questions about social determinants of health, information, trust, risk perception, testing and disease control, COVID-19 vaccination, and demographics. We analyzed data using bivariate logistic or linear regression models.
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