Patient presentations to the emergency department for mental health evaluations are common, with an estimated 1 in 4 adult visits made for this reason. These presentations are often accompanied by vague symptomatology, which may make it difficult to determine if they are because of another medical condition. Previous evaluations may bias future presentations, leading to premature closure before correctly identifying a causative underlying medical condition. Accurate, timely diagnosis improves health care costs by decreasing inappropriate treatments and unnecessary admissions and lowering the risk of recidivism. A 32-year-old woman presented with a complaint of recurrent neuropsychological symptoms attributed incorrectly to a primary mental disorder. On representation, she was found on computed tomography angiogram imaging to have pathognomonic findings for moyamoya disease. A short review of neuropsychological presentations previously attributed to moyamoya disease is reviewed. Because of the frequency with which we encounter patients for a mental health evaluation and the multifaceted harms of misdiagnosis, emergency providers should be familiar with moyamoya disease as a cause of mental disorders due to another medical condition.
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http://dx.doi.org/10.1016/j.acepjo.2025.100061 | DOI Listing |
J Neurochem
March 2025
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Synaptic homeostasis of the principal neurotransmitters glutamate and GABA is tightly regulated by an intricate metabolic coupling between neurons and astrocytes known as the glutamate/GABA-glutamine cycle. In this cycle, astrocytes take up glutamate and GABA from the synapse and convert these neurotransmitters into glutamine. Astrocytic glutamine is subsequently transferred to neurons, serving as the principal precursor for neuronal glutamate and GABA synthesis.
View Article and Find Full Text PDFMol Genet Genomic Med
March 2025
Department of Medical Genetics, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Background: While recently identified heterozygous PRPF8 variants have been linked to various human diseases, their role in neurodevelopmental disorders (NDDs) remains ambiguous. This study investigates the potential association between homozygous PRPF8 variants and NDDs. Most PRPF8 variants are primarily associated with retinal diseases; however, we analyze a family with multiple members diagnosed with NDDs.
View Article and Find Full Text PDFMicrobiol Immunol
March 2025
Niterra Co. Ltd., Japan.
Ambient humidity, temperature, and ozone influence the viability of airborne viruses, but their synergistic effects are poorly understood, particularly regarding ozone with humidity/temperature changes. Therefore, we examined the inactivation of airborne influenza viruses and coronaviruses under combinations of low ambient ozone concentrations, relative humidity (RH) levels, and temperatures typical of daily life. Viral fluid was atomized in a closed chamber conditioned with different combinations of these factors.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Research & Development, Yither Biotech Co Ltd, Shanghai, China.
The World Health Organization (WHO) has recently declared another global health emergency due to the rapidly spreading monkeypox (Mpox) outbreak in numerous African countries. To address the unmet need to contain the outbreak using the existing vaccines, this study developed a lyophilization process for an effective, scalable and affordable Mpox mRNA-LNP vaccine candidate to address the global health crisis. A comprehensive evaluation and optimization of the vaccine formulation (the type/concentration of cryoprotectants, the type/concentration of buffer system, as well as the mRNA concentration and reconstitution solvent) and the freeze-drying process parameters (freezing method, temperature, cooling rate and primary/secondary drying conditions) were conducted.
View Article and Find Full Text PDFObjectives: epidemiological data show growing numbers of patients with Alzheimer´s disease. Cognitive decline and progressive swallowing impairment lead to a significant deterioration of the nutrition status in this population. Early detection and treatment of malnutrition is important for the prognosis of the disease.
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