Female gonadal hormones, particularly estrogen and progesterone, are not only central to reproductive health but also play a crucial role in regulating mood, cognition, and overall brain health. These hormones have a significant impact on the central nervous system, influencing key processes such as neurotransmission, neuroplasticity, and brain development. Increasing evidence shows that hormonal fluctuations contribute to the onset and progression of mental health disorders that disproportionately affect women, particularly premenstrual dysphoric disorder (PMDD), postnatal depression (PND), and menopausal depression. This paper explores the current evidence regarding the neurobiological effects of female hormones on the brain and discusses the therapeutic approaches in conditions such as PMDD, PND, and menopausal depression.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882533 | PMC |
| http://dx.doi.org/10.3389/fphar.2025.1528544 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pain sensation and emotion induced by aromatase inhibitors: a new mouse model.
Pain
March 2025
Department of Anesthesiology and Pain Medicine, Peking University People's Hospital, Beijing, China.
Aromatase inhibitors (AIs) are crucial for hormone receptor-positive breast cancer patients, enhancing disease-free survival and significantly reducing the risk of distant metastasis and local recurrence. However, AI-induced pain and emotional distress can impair the quality of life and medication adherence, leading to premature discontinuation and increased mortality. In this study, we developed a novel mouse model to investigate these effects.
View Article and Find Full Text PDFUnder-recognized cardiovascular risk enhancers in women: A call to rethink clinical assessment on risk stratification.
Am J Prev Cardiol
March 2025
Servicio de Clínica Médica, Hospital Escuela Eva Perón, Argentina.
Objectives: Traditional cardiovascular risk (CVR) stratification does not consider CVR enhancers (CVRE). Women present under-recognized CVRE factors that may lead to arterial stiffness (AS). AS is associated with long-term cardiovascular disease.
View Article and Find Full Text PDFUsing estrogen and progesterone to treat premenstrual dysphoric disorder, postnatal depression and menopausal depression.
Front Pharmacol
February 2025
Department of Psychiatry, HER Centre Australia, The School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Female gonadal hormones, particularly estrogen and progesterone, are not only central to reproductive health but also play a crucial role in regulating mood, cognition, and overall brain health. These hormones have a significant impact on the central nervous system, influencing key processes such as neurotransmission, neuroplasticity, and brain development. Increasing evidence shows that hormonal fluctuations contribute to the onset and progression of mental health disorders that disproportionately affect women, particularly premenstrual dysphoric disorder (PMDD), postnatal depression (PND), and menopausal depression.
View Article and Find Full Text PDFDose-response relationship between carotenoid intake and risk of depressive symptoms in postmenopausal women.
Front Psychiatry
February 2025
University of Harbin Sport, Harbin, China.
Background: It is well known that postmenopausal women have an increased risk of depression, and there is a dose correlation between carotenoid intake and depression. However, there is no clear study on the relationship between carotenoids and the risk of depression in postmenopausal women. To evaluate the relationship between the prevalence of depression and carotenoid intake in postmenopausal women.
View Article and Find Full Text PDFObjectives: The extent to which menopause status contributes to depressive symptoms remains controversial. This study aimed to examine associations between menopausal status and depressive symptoms and the heterogeneity in these associations.
Methods: We conducted three consecutive national surveys of community-dwelling Australian women aged 18-79 years between October 2013 and July 2017.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!