Background: Cervical degenerative disc disease (DDD) significantly affects the quality of life in labor-intensive careers. When conservative measures fail, either anterior cervical discectomy and fusion (ACDF) or cervical disc arthroplasty (CDA) may be indicated. Although ACDF is the gold standard, it can limit motion, whereas CDA preserves motion and may reduce adjacent segment disease (ASD). Few studies compare these surgeries in physically demanding populations, and the influence of workers' compensation (WC) on outcomes is unclear. Therefore, the purpose of this study is to compare the outcomes of CDA versus ACDF in patients with labor-intensive jobs and to assess how workers' compensation (WC) status influences these outcomes.
Methods: In this prospective cohort study, 300 (CDA: 150, ACDF: 150) patients with 1- or 2-level cervical DDD with labor-intensive jobs were enrolled, including a subgroup of 60 WC patients (CDA: 30, ACDF: 30). Participants were followed for a minimum of 2 years. Data collected included demographic details, perioperative events, and complication rates. Functional outcomes were measured using the Visual Analog Scale for neck and arm pain (VAS-neck, VAS-arm) and the Neck Disability Index (NDI), with attention to timelines for returning to full-time work.
Results: CDA patients returned to full-time work faster (4.3 vs 6.7 months, p=.025). More CDA patients resumed work by 6 weeks (p=.018) and 3 months (p=.022), though these differences waned by 6 months. WC patients had slower returns overall (CDA WC: 7.5 vs 5.0 weeks for non-WC, p=.015). CDA showed greater NDI improvement at all time points and significantly lower ASD incidence (1.3% vs. 26.7%, p<.001). Complications were comparable.
Conclusion: CDA may facilitate faster work return, better recovery, and lower ASD risk in labor-intensive patients. WC status correlates with delayed recovery, suggesting a need for tailored approaches. Further research is necessary to confirm these findings and refine patient selection.
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http://dx.doi.org/10.1016/j.xnsj.2025.100590 | DOI Listing |
Int J Spine Surg
March 2025
Department of Neurosurgery, Hospital Lusíadas Porto, Porto, Portugal.
The evolution of spinal arthroplasty, a significant journey that began in the 1960s and 1970s, has seen remarkable progress. Initially designed to preserve motion at spinal segments and avoid complications associated with fusion surgeries, early designs faced setbacks due to rudimentary concepts and limited materials. However, the 1980s marked a turning point with the development of modern total disc replacement concepts, utilizing advanced materials such as titanium and polyethylene to improve implant longevity and integration.
View Article and Find Full Text PDFJ Sleep Res
March 2025
VA Portland Health Care System, Research Service, Portland, Oregon, USA.
Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury and post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related symptom severity and more neurological features indicative of prodromal synucleinopathy compared to RBD only. An early sign of neurodegenerative condition is autonomic dysfunction, which we sought to evaluate by examining heart rate variability during sleep. Participants with overnight polysomnography were recruited from the Veterans Affairs Portland Health Care System.
View Article and Find Full Text PDFJ Am Chem Soc
March 2025
School of Chemical Engineering and Technology, State Key Laboratory of Synthetic Biology, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, P. R. China, 300350.
While nucleic-acid-based cancer vaccines hold therapeutic potential, their limited immunogenicity remains a challenge due in part to the low efficiency of cytoplasmic delivery caused by lysosomal entrapment. In this work, we found that plasmids encoding both an antigen and a STING agonist protein adjuvant can self-assemble into coordination nanofibers, triggered by manganese ions. We developed a strategy to construct a DNA vaccine, termed MnO-OVA-CDA-mem, formed by the coencapsulation of manganese dioxide (MnO), an antigen-expressing plasmid (encoding ovalbumin, OVA), and an adjuvant enzyme-expressing plasmid (encoding STING agonist, CDA) within dendritic cell (DC) membranes.
View Article and Find Full Text PDFEMBO J
March 2025
Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and National Defense Medical Center, Taipei, 11490, Taiwan.
Bacteria in polymicrobial habitats are constantly exposed to biotic threats from bacteriophages (or "phages"), antagonistic bacteria, and predatory eukaryotes. These antagonistic interactions play crucial roles in shaping the evolution and physiology of bacteria. To survive, bacteria have evolved mechanisms to protect themselves from such attacks, but the fitness costs of resisting one threat and rendering bacteria susceptible to others remain unappreciated.
View Article and Find Full Text PDFSemin Arthritis Rheum
February 2025
Institute of Medical Science, University of Toronto, Toronto, Canada; Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada; University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada. Electronic address:
Objective: To identify candidate Systemic Lupus Erythematosus (SLE) domains from the literature for consideration towards the development of the SLE Core Outcome Set.
Methods: This was a comprehensive scoping literature review of SLE clinical trials and systematic reviews published since 2010. Studies were identified from 5 databases and were screened for eligibility.
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