The Treatment of Pancreatic Neuroendocrine Tumors - A Retrospective Single-Centre Study.

Pancreatic neuroendocrine tumors (PNETs) are uncommon cancers, but their overall incidence seems to be on the rise, possibly due to better detection with advancements in cross-sectional imaging techniques. This study consists of a retrospective analysis of PNET patients treated in the First Surgical Oncology Clinic over a period of 10 years. The patient files were evaluated, and the following parameters were taken into consideration: gender, age, primary tumor site, extension of the disease, metastatic sites, the therapeutic approach, type of surgery, histopathological results, postoperative mortality, and morbidity. Over the course of 10 years, there were 16 patients diagnosed with PNETs. Surgical interventions consisted in: pylorus-preserving pancreaticoduodenectomy in 5 cases, distal pancreatectomy in 3 cases, enucleation of the tumor in 4 cases, liver biopsy in 3 patients and one case in which choledochoduodenostomy and a liver biopsy were the treatment option. Mean length of stay was 10.6 days. In the study group, there were 4 cases that presented grade I-II complications (Clavien-Dindo). There was no case of postoperative or 30 days mortality. Conclusion: This study outlines the surgical management and clinicopathological findings of PNETs. Surgical therapy must be tailored to tumor and clinical characteristics.