Background: The overall health status of older adults in Japan has reportedly improved. However, it is unclear whether such improvement has occurred in the baby boomer generation, the oldest of whom turned 65 in 2015. In addition, the health status of oldest-old adults (aged > 85 years) was not examined extensively in previous studies. This study aimed to characterize trends in disability and chronic medical conditions in adults aged 65-89 years which includes the baby boomer generation.
Methods: From the Comprehensive Survey of Living Conditions (2001-2019), Patient Survey (1996-2020), and Vital Statistics (1995-2020), we documented disability rates, rates of treatment for nine chronic medical conditions (malignant neoplasms, diabetes mellitus, hypertension, ischemic heart disease, cerebrovascular diseases, pneumonia, fractures, osteoporosis, chronic kidney disease, and joint disorders), total mortality rates, and rates of mortality from specific causes (malignant neoplasms, heart diseases, cerebrovascular diseases, and pneumonia) in both sexes and in five age groups (65-69, 70-74, 75-79, 80-84, and 85-89 years).
Results: Overall, rates of disability decreased significantly in both sexes. Both total mortality rates and rates of mortality from specific medical causes declined significantly. These trends were observed in the baby boomer generation. The rates of treatment for most medical conditions also significantly decreased. However, the treatment rates of diabetes mellitus, pneumonia, and fractures in adults aged 85-89 years remained high or did not decrease. In contrast, the treatment rates of chronic kidney disease steadily increased over time.
Conclusions: Overall health status continues to improve in older Japanese adults, including the baby boomer generation and the oldest-old cohort. However, for several diseases, no improvement was observed; thus, further public health interventions are necessary.
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http://dx.doi.org/10.1186/s12877-025-05799-8 | DOI Listing |
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
Ann Med
December 2025
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.
Methods: Participants were obtained from the RealDTC study between December 2016 and December 2022.
J Cell Mol Med
March 2025
Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, P. R. China.
The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets of AD with depression. We confirmed a positive correlation between AD and depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related to AD.
View Article and Find Full Text PDFObesity (Silver Spring)
March 2025
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Objective: The objective of this study was to evaluate associations of early-pregnancy plasma per- and polyfluoroalkyl substances (PFAS) with maternal post-pregnancy weight trajectory parameters.
Methods: We studied 1106 Project Viva participants with measures of early-pregnancy plasma concentrations of eight PFAS. We measured weight at in-person visits at 6 months and 3, 7, and 12 years after pregnancy and collected self-reported weight via annual questionnaires up to 17 years after pregnancy.
Global Spine J
March 2025
Combined Neurosurgical and Orthopaedic Spine Program, University of British Columbia, Vancouver, BC, Canada.
Study DesignNarrative Review.ObjectivesTo summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study.MethodsA narrative review of all published manuscripts from the EPOSO study was undertaken.
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