Maladaptive feeding comprises unhealthy eating patterns that jeopardize survival, including over- and underconsumption. These behaviors are often coordinated by endogenous opioid receptors (EORs). Here, we explore the involvement of EORs in obesity and anorexia nervosa (AN), two disorders associated with dysregulated feeding behavior and relevant animal models. While seemingly opposing metabo-psychiatric states, our goal is to highlight common circuit and synaptic mechanisms underlying obesity and AN with a focus on EOR functionality. We examine the neural substrates underlying maladaptive feeding and comorbid conditions including pain, suggesting a role for EOR-driven plasticity in the pathogenesis of both obesity and AN.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885478 | PMC |
| http://dx.doi.org/10.1038/s41467-025-57515-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feasibility and Links Between Emotions, Physical States, and Eating Behavior in Patients After Metabolic Bariatric Surgery: Experience Sampling Study.
JMIR Form Res
March 2025
Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, The Netherlands.
Background: Lifestyle modification is essential to achieve and maintain successful outcomes after metabolic bariatric surgery (MBS). Emotions, physical states, and contextual factors are considered important determinants of maladaptive eating behavior, emphasizing their significance in understanding and addressing weight management. In this context, experience sampling methodology (ESM) offers promise for measuring lifestyle and behavior in the patient's natural environment.
View Article and Find Full Text PDFEndogenous opioid receptors and the feast or famine of maladaptive feeding.
Nat Commun
March 2025
Department of Psychology, Behavioral and Systems Neuroscience, Rutgers University, Piscataway, NJ, USA.
Maladaptive feeding comprises unhealthy eating patterns that jeopardize survival, including over- and underconsumption. These behaviors are often coordinated by endogenous opioid receptors (EORs). Here, we explore the involvement of EORs in obesity and anorexia nervosa (AN), two disorders associated with dysregulated feeding behavior and relevant animal models.
View Article and Find Full Text PDFOperant light self-administration in mice and its relevance to digital technology-based disorders.
J Behav Addict
March 2025
3The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, People's Republic of China.
Behavioral addictions share symptomatological features with substance addiction. From the associative learning perspective, these characteristics include excessive and unregulated self-administration of sensory and other reinforcers, potentially reflecting the transition from goal-directed actions (action → outcome associations) to habitual responses (stimulus → response associations). In laboratory mice, light stimulation at an optimal intensity possesses some incentive properties and a brief light pulse represents an effective reinforcer for persistent operant responding.
View Article and Find Full Text PDFAppearance concerns are a key feature in body dysmorphic disorder and eating disorders, and they have been found to be a common feature of social anxiety disorder. Given the lack of transdiagnostic treatments for appearance concerns, we developed a preliminary text-based intervention targeting appearance-related safety behaviors (ARSBs; i.e.
View Article and Find Full Text PDFDietary and health risk behaviors for metabolic diseases in different age groups: a cross-sectional study in Chongqing, China.
BMC Public Health
February 2025
Chongqing Medical University, Chongqing, 401331, China.
Background: The study aimed to investigate the relationship between the frequency of metabolic diseases (MetD) and dietary behaviors as well as health risk behaviors in various age groups.
Methods: This Cross-Sectional study involved 12,215 participants, and the relationship between MetD and health risk behaviors was discussed using Pearson chi-square tests and unordered binary logistics regression. The Apriori algorithm was used to explore and analyze the combination patterns of health risk behaviors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!