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Using HINTS in acute vestibular syndrome: A practical guide for the acute care physician.
J R Coll Physicians Edinb
March 2025
Consultant in Stroke Medicine, Queens Medical Centre, Nottingham, UK.
Acute vestibular syndrome (AVS) is a common clinical presentation. Common causes include peripheral, self-limiting labyrinthine disorders, but a significant proportion are caused by posterior circulation stroke (PoCS). Delineating between a peripheral versus central cause in AVS is challenging for acute care physicians, but a simple, three-step bedside test known collectively as the HINTS examination may be useful.
View Article and Find Full Text PDFLogic of crisis management practice in handling the COVID-19 pandemic: Experiences from two Swedish public-sector organizations.
J Emerg Manag
March 2025
Mid-Sweden University, Risk and Crisis Research Center (RCR), Östersund, Sweden.
This study aims to examine the ambiguity and uncertainty surrounding crisis management and the implementation of national recommendations in two public-sector organizations during the initial phase of the coronavirus disease 2019 (COVID-19) pandemic. This study is based on two case studies: a municipality and a county administrative board in Sweden. Data were collected through interviews, surveys, and participation in meetings, and they were analyzed using a practice theory lens.
View Article and Find Full Text PDFIntergroup-statement: statement of the german ovarian cancer commission, the North-Eastern German Society of gynecological Oncology (NOGGO), AGO Austria and AGO Swiss regarding the use of homologous repair deficiency (HRD) assays in advanced ovarian cancer.
Arch Gynecol Obstet
March 2025
Department for Gynecology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Introduction: Homologous recombination deficiency (HRD) is a key biomarker in the management of high-grade serous ovarian cancer (HGSOC), guiding treatment decisions, particularly regarding the use of poly(ADP-ribose) polymerase inhibitors (PARPi). As multiple HRD assays are available, each with distinct methodologies and cutoff values, the interpretation and clinical application of HRD testing remain complex. This intergroup statement, endorsed by the German Ovarian Cancer Commission, NOGGO, AGO Austria, and AGO Swiss, aims to provide guidance on the indications, appropriate use, and limitations of HRD testing in ovarian cancer.
View Article and Find Full Text PDFNavigating artificial general intelligence development: societal, technological, ethical, and brain-inspired pathways.
Sci Rep
March 2025
Amrita School of Computing, Amrita Vishwa Vidyapeetham, Amritapuri, Amritapuri, Kerala, 690525, India.
This study examines the imperative to align artificial general intelligence (AGI) development with societal, technological, ethical, and brain-inspired pathways to ensure its responsible integration into human systems. Using the PRISMA framework and BERTopic modeling, it identifies five key pathways shaping AGI's trajectory: (1) societal integration, addressing AGI's broader societal impacts, public adoption, and policy considerations; (2) technological advancement, exploring real-world applications, implementation challenges, and scalability; (3) explainability, enhancing transparency, trust, and interpretability in AGI decision-making; (4) cognitive and ethical considerations, linking AGI's evolving architectures to ethical frameworks, accountability, and societal consequences; and (5) brain-inspired systems, leveraging human neural models to improve AGI's learning efficiency, adaptability, and reasoning capabilities. This study makes a unique contribution by systematically uncovering underexplored AGI themes, proposing a conceptual framework that connects AI advancements to practical applications, and addressing the multifaceted technical, ethical, and societal challenges of AGI development.
View Article and Find Full Text PDFThe Impact of Coronavirus Disease 2019 (COVID-19) on Vulnerable Communities: What the Clinician Should Know.
Infect Dis Clin North Am
March 2025
Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
The COVID-19 pandemic unmasked striking health disparities within the US healthcare system and significantly impacted vulnerable populations. While much attention on vulnerability has been directed toward older individuals with underlying medical conditions, key populations-including the uninsured, racial and ethnic minorities, and pregnant individuals-were considerably affected and require intervention. This review examines the barriers these populations encountered and outlines how clinicians can engage at the provider, practice, community, and national levels to advance health equity and improve health outcomes for these groups in the post-pandemic era.
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