While using fully autonomous vehicles is expected to radically change the way we live our daily lives, it is not yet available in most parts of the world, so we only have sporadic results on passenger reactions. Furthermore, we have very limited insights into how passengers react to an unexpected event during the ride. Previous physiological research has shown that passengers have lower levels of anxiety in the event of a human-driven condition compared to a self-driving condition. The aim of our current study was to investigate these differences in unexpected road events in real-life passenger experiences. All subjects were driven through a closed test track in human-driven and then self-driving mode. During the journey, unforeseen obstacles were encountered on the path (deer and human-shaped dummies appeared). Using physiological measurements (EEG, eye movements, head movements and blinking frequencies) our results suggest that passengers had moderate affective preferences for human-driven conditions. Furthermore, multifractal spectra of eye movements and head movements were wider and blinking frequencies were decreased during unexpected events. Our findings further establish real-world physiological measurements as a source of information in researching the acceptance and usage of self-driving technologies.
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http://dx.doi.org/10.1038/s41598-024-81960-4 | DOI Listing |
Epilepsia
March 2025
University of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Objective: We analyzed the long-term safety and effectiveness of fenfluramine (FFA) in patients with Dravet syndrome (DS) in an open-label extension (OLE) study after participating in randomized controlled trials (RCTs) or commencing FFA de novo as adults.
Methods: Patients with DS who participated in one of three RCTs or were 19 to 35 years of age and started FFA de novo were included. Key endpoints were: incidence of treatment-emergent adverse events (TEAEs) in the safety population, and median percentage change in monthly convulsive seizure frequency (MCSF) from the RCT baseline to end of study (EOS) in the modified intent-to-treat (mITT) population.
Sleep Med
February 2025
Departamento de Neurocirurgia. Hospital A Beneficência de São Paulo, São Paulo, Brazil; Departamento de Neurologia e Neurocirurgia. Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address:
Melatonin has been shown to improve sleep quality in Parkinson's disease (PD) patients with good safety and tolerability. Beyond its neurological benefits, emerging evidence suggests that melatonin may exert cardioprotective effects, which could be relevant in the context of sudden unexpected death in PD (SUDPAR). PD is associated with high mortality rates, and autonomic dysfunction and cardiac abnormalities may play a role in SUDPAR.
View Article and Find Full Text PDFClin Radiol
February 2025
Department of Oncology Center, Lishui Municipal Central Hospital, Lishui, Zhejiang 323000, China; The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang 323000, China. Electronic address:
Aim: Systemic chemotherapy plus immune checkpoint inhibitors (ICIs) are first-line treatment for advanced non-small cell lung cancer (NSCLC). However, elderly patients typically have comorbidities that tend to limit the use of chemotherapy at standard dosage and frequency. Drug-eluting bead bronchial arterial chemoembolisation (DEB-BACE)/bronchial arterial chemoembolization (BACE) represents options in such patients.
View Article and Find Full Text PDFEpilepsia
March 2025
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Objective: Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure-induced disruption of vital physiological systems. The objective of this study was to characterize seizure-induced physiological dysfunction leading to death in SS rats and determine the importance of time of day of seizures regarding mortality rates.
Methods: Male and female SS rats were surgically implanted with an arterial pressure telemeter and chronically housed in a custom plethysmograph.
Gen Thorac Cardiovasc Surg Cases
March 2025
Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan.
Background: Rapid deployment aortic valve replacement (RDAVR) has been widely adopted, but concerns about postoperative paravalvular leak (PVL) associated with its use remain. PVL is linked to an increased risk of long-term mortality; however, there is no consensus on its treatment.
Case Presentation: Case 1: A 76-year-old female with severe aortic stenosis underwent RDAVR via median sternotomy.
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