1,2-Benzisothiazol-3(2H)-one (BIT) has strong antibacterial activity, but its water insolubility and skin toxicity effects hinder its application in the antibacterial domain of the fuel system. In this study, benzisothiazolinone quaternized chitosan derivative (HACCBIT) was synthesized by intercalated quaternized chitosan with 1,2-benzisothiazolin-3-one-based anions (BIT-COO-) via ion-exchange reactions. HACCBIT exhibits enhanced aqueous solubility and remarkable biocompatibility. It exhibited significant antibacterial and antibiofilm effects against gram-negative bacteria (Escherichia coli), gram-positive bacteria (Staphylococcus aureus) as well as microbial contaminants isolated from stored aviation fuels (Sediminibacterium salmoneum and Lysinibacillus sphaericus) by induced cytoplasmic leakage and membrane permeability. Furthermore, HACCBIT also inhibited the corrosion of the 7050‑aluminum alloy used in fuel tanks for >84 h. This study demonstrated that covalently linking BIT to chitosan via electronic splicing techniques, effectively mitigates the deficiencies of BIT while demonstrating a unique bactericidal action against bacteria in aviation fuel. It also safeguards metal components within fuel tanks, thereby enhancing the potential of polysaccharide derivatives as effective antibacterial agents in fuel systems.
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