Acute iliofemoral deep vein thrombosis (DVT) is associated with higher rates of severe chronic symptoms and complications, and in rare cases with acute limb ischemia. Early detection is a key to provide prompt treatment, including endovascular intervention, in selected patients. When iliofemoral DVT is related to external compression of the left iliac vein by the right common iliac artery is termed May-Thurner syndrome. Approximately, 20% to 50% of patients with chronic DVT will develop post-thrombotic syndrome, a collection of symptoms including lower extremity edema, skin changes, vein dilation, pain, fatigue, and ulcer formation.
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http://dx.doi.org/10.1016/j.iccl.2024.11.014 | DOI Listing |
Mycoses
March 2025
Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), and Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Cologne, Germany.
Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug-resistant species such as Candida auris, which is associated with outbreaks. Guidelines on the management of candidaemia emphasise identification of species and determination of antifungal susceptibility to guide appropriate treatment, performing relevant investigations to rule out deep-seated infection, and removal of central venous catheters.
View Article and Find Full Text PDFClin Spine Surg
March 2025
Department of Orthopedics, Beth Israel Deaconess Medical Center, Harvard Medical School.
Study Design: Systematic review and meta-analysis.
Objective: To determine whether venous thromboembolism (VTE) prophylaxis is necessary after spine trauma and to assess the efficacy and safety profiles of anticoagulation agents.
Summary Of Background Data: Venous stasis, endothelial disruption, hypercoagulability, and orthopedic injury in spine trauma predispose 12%-64% of patients to deep vein thrombosis (DVT).
Front Med (Lausanne)
February 2025
Department of Pulmonary and Critical Care Medicine, Zhongshan People's Hospital, Zhongshan, China.
Deep vein thrombosis (DVT) of the legs is a rare but clinically important complication of pneumonia. We report a case of a 51-year-old man who was admitted to the hospital with fever, cough, and dyspnea. Next-generation sequencing confirmed the diagnosis of pneumonia.
View Article and Find Full Text PDFJ Knee Surg
March 2025
Orthopaedic Surgery, Massachusetts General Hospital/ Harvard Medical School, Boston, United States.
Background: The rising demand for unicompartmental knee arthroplasty (UKA) in the United States has led to high one-year patient satisfaction rates. However, some patients experience substantial declines in patient-reported outcome measures (PROMs) post-operatively, which we refer to as "Minimal Clinically Importance Difference for Worsening " (MCID-W). We sought to define MCID-W values for specific PROMs and identify risk factors associated with PROMIS Physical Function Short Form 10a (PROMIS PF-10a) declines after UKA.
View Article and Find Full Text PDFMedicine (Baltimore)
March 2025
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
The aim was to investigate the causal relationship between the lipidome and deep vein thrombosis (DVT) while identifying and quantifying the role of metabolites as potential mediators. Two-sample Mendelian randomization (MR) analysis of lipid species (n = 7174) and DVT (6767 cases and 330,392 controls) was performed using pooled data from genome-wide association studies. In addition, we quantified the proportion of metabolite-mediated lipidomic effects on DVT using 2-step MR.
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