Hypertension is a major contributor to morbidity and mortality in the United States, and its management remains a significant challenge for clinicians. Transcatheter renal denervation targeting sympathetic nervous system overactivity offers an additive benefit to medications for patients with uncontrolled hypertension as well as for patients who are not able or unwilling to be treated with medications. Two devices were recently approved for commercial use that employ radiofrequency ablative and ultrasound energy for renal denervation. Both devices have shown durable treatment effects up to 3 years with minimal device-related safety concerns.
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| http://dx.doi.org/10.1016/j.iccl.2024.11.008 | DOI Listing |
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Background And Aims: Catheter-based renal denervation (RDN) is a safe and effective alternative treatment for hypertension. However, data on patient preferences are limited. This study sought to delineate preferences for RDN among Veterans with difficult-to-control hypertension at an urban VA Medical Center with the goal of optimizing management and referral practices in hypertensive Veterans.
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March 2025
İzmir Democracy University Faculty of Medicine, Buca Seyfi Demirsoy Training and Research Hospital, Department of Gynecologic Oncology, İzmir, Türkiye.
Objective: To evaluate the effect of para-aortic lymphadenectomy on blood pressure changes in endometrial cancer patients.
Materials And Methods: This retrospective study included patients with endometrial cancer treated surgically between 2017 and 2023. Patients undergoing para-aortic lymphadenectomy, up to the renal artery, in a non-nerve-sparing fashion, were compared with those undergoing pelvic lymphadenectomy or sentinel lymph node mapping.
Mechanisms involved in cardiovascular and hydroelectrolytic changes in dehydrated high-fat diet-fed rats.
Am J Physiol Regul Integr Comp Physiol
March 2025
Department of Physiology and Pathology, School of Dentistry, UNESP - São Paulo State University, Araraquara - SP, Brazil.
Obesity is increasingly prevalent worldwide, and climate change is exacerbating water shortages, leading to dehydration. Both obesity and dehydration cause increased arterial pressure (AP), fluid electrolytic imbalance, and neuroinflammation. Thus, the present study aimed to verify the changes in the cardiovascular system, hydroelectrolytic balance and microglia and neuronal activation in rats fed with a high-fat diet (HFD) in response to 24 h of water deprivation (WD) and the possible mechanisms involved.
View Article and Find Full Text PDFRenal Denervation: A Review of Current Devices, Techniques, and Evidence.
Interv Cardiol Clin
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Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Cardiovascular Medicine, Chester County Hospital, West Chester, PA 19380, USA. Electronic address:
Hypertension is a major contributor to morbidity and mortality in the United States, and its management remains a significant challenge for clinicians. Transcatheter renal denervation targeting sympathetic nervous system overactivity offers an additive benefit to medications for patients with uncontrolled hypertension as well as for patients who are not able or unwilling to be treated with medications. Two devices were recently approved for commercial use that employ radiofrequency ablative and ultrasound energy for renal denervation.
View Article and Find Full Text PDFSafety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension.
Clin Exp Hypertens
December 2025
Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
This study investigated the safety and efficacy of the HyperQure™ extravascular renal denervation (RDN) system in a swine model of mild hypertension. Ten female pigs were fed a 3% salt diet to induce hypertension and underwent either extravascular RDN using the HyperQure™ RDN system ( = 7) or a sham procedure ( = 3). Blood pressure (BP) was continuously monitored using implanted transmitters, and safety assessments were conducted via computed tomography angiography (CTA) at 28 days post-procedure.
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