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Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life.
J Immunol
February 2025
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.
Food allergy has had a rapid rise in prevalence, and thus it is important to identify approaches to limit the development of food allergy early in life. Because maternal dietary supplementation with α-tocopherol (α-T), an isoform of vitamin E, during pregnancy and nursing increases neonate plasma levels of α-T and can limit neonate development of other allergies, we hypothesized that α-T can limit development of food allergy. To assess this, male mice with mutations in their skin barrier genes (FT-/- mice) were mated with wild-type females that received a diet supplemented with α-tocopherol or a control diet.
View Article and Find Full Text PDFSevere brainstem dysfunction in a neonate following intrauterine myelomeningocele repair: illustrative case.
J Neurosurg Case Lessons
March 2025
Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Background: Caudal brainstem dysfunction associated with Chiari malformation type II (CM-II) is an important source of morbidity and mortality in neonates with myelomeningocele (MMC).
Observations: Prenatal MMC repair has been shown to improve or even completely reverse the extent of hindbrain herniation (HH) associated with CM-II as well as reduce the incidence of hydrocephalus requiring CSF diversion, possibly leading to a reduction in CM-II-related symptoms in these children. Urgent CSF diversion and potential CM-II decompression surgery are typically the preferred treatments for infants demonstrating caudal brainstem dysfunction, although contemporary reports have described a decreased need for both CSF diversionary surgery and CM-II decompression following prenatal MMC repair.
Healthcare related barriers and enablers for weight management among pregnant women with overweight and obesity: a rapid scoping review.
BMC Pregnancy Childbirth
March 2025
School of Nursing and Midwifery, Centre for Quality and Patient Safety Research, Deakin University, 221 Burwood Hwy, Burwood, 3125, VIC, Australia.
Background: Overweight and obesity in pregnancy are associated with health risks for women and babies. Providing effective weight management during pregnancy is necessary to support appropriate gestational weight gain and improve outcomes for women and their infants. This study aimed to synthesise evidence documenting healthcare-related barriers and enablers for weight management among pregnant women with overweight or obesity in English-speaking high-income countries.
View Article and Find Full Text PDFDermoid cyst associated with segmental multicystic renal dysplasia: A rare case.
Urol Case Rep
March 2025
Department of Pediatric Surgery, Fattouma Bourguiba Hospital, Monastir, Tunisia.
Most multicystic dysplastic kidneys (MCDKs) are detected prenatally, yet there is no clear consensus on initial evaluation and follow-up. We report the case of a 4-year-old male diagnosed with right pyelocalyceal dilation in utero, confirmed postnatally as MCDK. Follow-up ultrasounds revealed rapid growth of three upper pole cysts, reaching 8 cm.
View Article and Find Full Text PDFRapid prenatal diagnosis of Down syndrome in a fetus with bilateral pleural effusion and hydrops fetalis in the early second trimester by quantitative fluorescent polymerase chain reaction using the DNA extracted from uncultured amniocytes.
Taiwan J Obstet Gynecol
March 2025
Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Institute of Clinical and Community Health Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical & Health Science, Asia University, Taichung, Taiwan. Electronic address:
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