Objective: Hypertriglyceridemia (HTG) is a rare cause of acute pancreatitis (AP) in pregnancies and has emerged as an aggravating factor of severe pancreatitis. To enhance the diagnosis and management of HTG-induced AP during pregnancy by improving early recognition, optimizing treatment strategies, and minimizing maternal and fetal complications.
Case Report: This is a 29-year-old multigravida woman at a gestational age of 34 weeks and 2 days who presented with sudden abdominal pain and vomiting. She had severe hypertriglyceridemia (7855 mg/dL) and was diagnosed with acute pancreatitis. After an emergency cesarean section, the patient received aggressive hydration, as well as fenofibrate and gemfibrozil as lipid-lowering agents, along with other supportive care. This treatment led to a successful recovery.
Conclusion: The management of HTG-induced AP must consider both maternal and fetal health, with options such as lipid-lowering agents and plasmapheresis being explored, further research was required to ascertain their safety during pregnancy.
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http://dx.doi.org/10.1016/j.tjog.2025.01.003 | DOI Listing |
Indian J Gastroenterol
March 2025
Department of Gastroenterology, Surat Institute of Digestive Science, Majura Gate, Ring Road, Surat, 395 002, India.
Rheumatol Int
March 2025
Department of Rheumatology and Connective Tissue Diseases, Medical University, St. Jaczewskiego 8, 20-090, Lublin, Poland.
Pancreatic panniculitis (PP) and arthritis may be extrapancreatic manifestations of pancreatic disease. The triad of pancreatic disease, panniculitis and polyarthritis, described in the literature as the PPP syndrome, is sometimes observed in patients with acute or chronic pancreatitis, pancreatic cancer or neuroendocrine tumors (NETs). We present a 60-year-old man with polyarthritis and clinically aggressive PP of the limbs.
View Article and Find Full Text PDFRheumatology (Oxford)
March 2025
Harvard Medical School, Division of Rheumatology, Allergy, and Immunology, The Edward A. Fox Chair in Medicine, Massachusetts General Hospital, Executive Chairman, The IgG4ward! Foundation, Boston, MA, USA.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease that is believed but not confirmed to have an autoimmune origin. Since its discovery nearly two decades ago, our understanding of its pathophysiology and clinical manifestations has grown substantially. Early diagnosis and treatment of this elusive disease can prevent substantial organ damage from end-stage fibrosis.
View Article and Find Full Text PDFCureus
February 2025
Internal Medicine, Catholic Health, Buffalo, USA.
Pancreatic pseudocysts are a complication of both acute and chronic pancreatitis that usually develop four to six weeks from the onset of pancreatitis. Alcoholic pancreatitis is the most important risk factor for developing such cysts, although non-alcoholic cases do also occur. This is the case of a 58-year-old male patient who presented to our emergency department with a two-day history of abdominal pain, nausea, vomiting, and inability to tolerate oral food and liquids.
View Article and Find Full Text PDFClin Exp Pharmacol Physiol
May 2025
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Hypertriglyceridaemia (HTG) is a common and well-established aetiology of acute pancreatitis (AP). Although the underlying pathophysiology of hypertriglyceridaemic pancreatitis (HTGP) is complex, some animal models of HTAP have been successfully reproduced by repeated caerulein injections based on HTAP. However, most of the current HTGP models are critically dependent on the "two-attack" of cholecystokinin analogue, which may not be consistent with the fact of HTGP aetiologies due to ignored the initial effects of HTG in the development of HTGP.
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