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Two-Year Hypertension Incidence Risk Prediction in Populations in the Desert Regions of Northwest China: Prospective Cohort Study.
J Med Internet Res
March 2025
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Background: Hypertension is a major global health issue and a significant modifiable risk factor for cardiovascular diseases, contributing to a substantial socioeconomic burden due to its high prevalence. In China, particularly among populations living near desert regions, hypertension is even more prevalent due to unique environmental and lifestyle conditions, exacerbating the disease burden in these areas, underscoring the urgent need for effective early detection and intervention strategies.
Objective: This study aims to develop, calibrate, and prospectively validate a 2-year hypertension risk prediction model by using large-scale health examination data collected from populations residing in 4 regions surrounding the Taklamakan Desert of northwest China.
Mendelian randomization analysis of the causal association between metabolite and skin cancer.
Dermatol Reports
March 2025
Oncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province.
Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach.
View Article and Find Full Text PDFMaternal Inflammatory Proteins in Pregnancy and Neurodevelopmental Disorders at Age 10 Years.
JAMA Psychiatry
March 2025
Center for Neuropsychiatric Schizophrenia Research (CNSR& Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Importance: Maternal inflammation during pregnancy has been associated with an increased risk of neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD) and autism, and cognitive deficits in early childhood. However, little is known about the contributions of a wider range of inflammatory proteins to this risk.
Objective: To determine whether maternal inflammatory proteins during pregnancy are associated with the risk of NDDs and executive functions (EF) in middle childhood and to identify protein patterns associated with NDDs and EF.
Developing a Strategy for Prevention of Avoidable Postcolonoscopy Colorectal Cancers: Current and Future Perspectives.
Gastroenterology
March 2025
Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Dynamic Bonding for In-Situ Welding of Multilayer Elastomers Enables High-Performance Wearable Electronics for Machine Learning-Assisted Active Rehabilitation.
Adv Mater
March 2025
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Patients with hand dysfunction require joint rehabilitation for functional restoration, and wearable electronics can provide physical signals to assess and guide the process. However, most wearable electronics are susceptible to failure under large deformations owing to instability in the layered structure, thereby weakening signal reliability. Herein, an in-situ self-welding strategy that uses dynamic hydrogen bonds at interfaces to integrate conductive elastomer layers into highly robust electronics is proposed.
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