Blueberries with high anthocyanin content undergo various postharvest qualitative losses. In this work, eco-friendly coatings were developed for maintaining postharvest blueberry quality using lipopeptides (LPs), gelatin, and sodium carboxymethyl cellulose. The addition of LPs decreased the surface tension of coating film and thus exhibited lower water contact angle (95.53 ± 0.94°) than unmodified one (112.33 ± 0.73°). We demonstrated that LPs-modified coating not only extended the shelf life of blueberries by 12.5 % but also resulted in a reduction of 3.83 lg CFU/g in moulds and yeasts count compared to uncoated one. Furthermore, blueberries with higher anthocyanin content (75.75 mg 100 g) were recognized in LPs-modified coating treatment, which was further validated in anthocyanin biosynthesis genes expression through RT-qPCR. Our results demonstrate the effect of LPs-modified coating treatment on postharvest blueberry quality and anthocyanin biosynthesis genes expression. This work provides a promising strategy to produce biobased antimicrobial packaging system.
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http://dx.doi.org/10.1016/j.ijbiomac.2025.141590 | DOI Listing |
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
J Cell Mol Med
March 2025
Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Joubert syndrome (JS) is a rare neurodevelopmental disorder associated with mutations in genes involved in ciliary function. Germline variants in CPLANE1 have been implicated in JS. In this study, we investigated a family with three adverse pregnancies characterised by fetal malformations consistent with JS.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
March 2025
Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: The swift rise in the prevalence of Alzheimer's disease (AD) alongside its significant societal and economic impact has created a pressing demand for effective interventions and treatments. However, there are no available treatments that can modify the progression of the disease.
Methods: Eight AD brain tissues datasets and three blood datasets were obtained.
EBioMedicine
February 2025
Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK; Institute for Clinical Research and Systems Medicine, Health and Medical University, Potsdam, Germany.
Background: Maternal smoking and foetal exposure to nicotine and other harmful chemicals in utero remains a serious public health issue with little knowledge about the underlying genetics and consequences of maternal smoking in ageing individuals. Here, we investigated the epidemiology and genomic architecture of maternal smoking in a middle-aged population and compare the results to effects observed in the developing foetus.
Methods: In the current project, we included 351,562 participants from the UK Biobank (UKB) and estimated exposure to maternal smoking status during pregnancy through self-reporting from the UKB participants about the mother's smoking status around their birth.
Trends Plant Sci
March 2025
Molecular Plant Nutrition, Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany. Electronic address:
Root age-dependent processes have remained poorly understood. Here, we define root age-related terms in their eco-/physiological context, provide a synthesis of read-outs and traits characterizing root senescence in different root types, and follow their modulation in the light of metabolic, hormonal, and genetic control. Evidence for an endogenously regulated senescence program in roots includes changes in root anatomy, metabolism, and color, decrease in root activity, increasing levels of stress-related hormones, and increasing expression of certain transcription factors (TFs) or genes involved in oxidative stress defense.
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