This publication explores the characteristics, threats, and challenges posed by fourth-generation chemical warfare agents - Novichoks. These highly toxic agents, recently introduced to the international security landscape, represent a significant risk not only to military forces, but also to civilian populations, especially in the context of potential terrorist attacks. The study examines the molecular structure, toxicity, and physiological effects of Novichoks, underscoring their resistance to conventional decontamination methods and their rapid, severe impact on human health. Through the case studies, including the poisoning incidents involving Sergei Skripal, Alexei Navalny, and other high-profile cases, this publication illustrates the real-world implications of these agents in acts of targeted violence. It also discusses the international regulatory measures established by organizations such as the Organization for the Prohibition of Chemical Weapons (OPCW) and highlights EU and NATO policies aimed at preventing the proliferation and use of Novichoks and similar agents.
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http://dx.doi.org/10.1016/j.fct.2025.115371 | DOI Listing |
Food Chem Toxicol
March 2025
Military University of Technology, Faculty of Security, Logistics and Management, ul. Gen. S. Kaliskiego 2, 00-908 Warsaw.
This publication explores the characteristics, threats, and challenges posed by fourth-generation chemical warfare agents - Novichoks. These highly toxic agents, recently introduced to the international security landscape, represent a significant risk not only to military forces, but also to civilian populations, especially in the context of potential terrorist attacks. The study examines the molecular structure, toxicity, and physiological effects of Novichoks, underscoring their resistance to conventional decontamination methods and their rapid, severe impact on human health.
View Article and Find Full Text PDFMicrob Biotechnol
March 2025
Commonwealth Scientific and Industrial Research Organisation (CSIRO) Agriculture and Food, Acton, Australian Capital Territory, Australia.
Bacteria and fungi produce a wide range of specialised metabolites, including volatile organic compounds (VOCs) that can act as signals or act directly to inhibit niche-competing microbes. Despite their ecological importance, most VOCs involved as signalling compounds remain uncharacterised. We have previously screened a collection of Actinobacteria strains sourced from Western Australia for their ability in vitro to suppress the growth of plant fungal pathogens.
View Article and Find Full Text PDFArch Toxicol
March 2025
Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (Ctex), Av. das Américas 28705, Área 4, Rio de Janeiro-RJ, 23020-470, Brazil.
Recent events involving nerve agents of the A-Series, a once elusive class of chemical warfare agents, have provoked a great concern in the international community. In this paper, continuing our research efforts in Medicinal Chemistry at the Brazilian Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN) (an OPCW-designated Laboratory for environmental samples), we explore ANMP, an A-230 surrogate, in the search for new treatment options for intoxications caused by these chemicals. Five isatin-pyridine oxime hybrids were evaluated as acetylcholinesterase (AChE) reactivators using a modified Ellman's assay.
View Article and Find Full Text PDFToxicol In Vitro
May 2025
Department of Regulatory and Forensic Toxicology, Institute of Medical Expertises in Łódź, ul. Aleksandrowska 67/93, 91-205 Łódź, Poland; Laboratory of Innovative Toxicological Research and Analyzes, Institute of Medical Studies, Medical College, Rzeszów University, Al. mjr. W. Kopisto 2a, 35-959 Rzeszów, Poland. Electronic address:
Chloropicrin, historically infamous as a chemical warfare agent during World War I, has recently resurfaced in global conflicts, prompting a reevaluation of its acute toxicological significance. This study addresses the historical knowledge gap surrounding chloropicrin by employing in silico toxicology methods to estimate toxicophores and predict acute toxicity across various exposure routes. Allegations of its use in recent conflicts necessitate a deeper understanding of its toxicological profile, particularly in modern warfare scenarios.
View Article and Find Full Text PDFMolecules
February 2025
Institute of Chemistry, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.
The course and kinetics of the reactions of sulfur mustard, nitrogen mustard and their selected analogues with sodium ethoxide were studied using a gas chromatograph coupled with a mass spectrometer. 2-chloroethyl ethyl sulfide (CEES), a monofunctional analogue of sulfur mustard (HD), bis(2-chloroethyl) ether (BCEE), an oxygen analogue of sulfur mustard, and bis(2-chloroethyl)amine, an analogue of nitrogen mustard HN-3, in which one hydrogen atom remains unsubstituted with a chloroethyl group, were used as imitators of mustards. For the study, the last mentioned compound was given the acronym HN-0.
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