Objective: To compare lamina cribrosa (LC) parameters in non-glaucomatous eyes with pseudoexfoliation syndrome (PXFS) and healthy control eyes to assess structural alterations that may contribute to early glaucoma pathophysiology.
Design: Retrospective, cross-sectional study.
Participants: Fifty eyes with non-glaucomatous PXFS and 50 healthy, age-matched control eyes.
Methods: All participants underwent spectral-domain optical coherence tomography with enhanced-depth imaging. LC parameters were measured at the superior mid-peripheral, central, and inferior mid-peripheral regions. Comparisons between groups were assessed with paired t-tests for continuous data and the McNemar test for categorical data. Mixed effects model analysis was utilized to identify factors associated with lamina cribrosa thickness (LCT).
Main Outcome Measures: Measurements of LCT, lamina cribrosa curvature depth (LCCD), curvature index (LCCI), and prelaminar tissue thickness (PLTT).
Results: Eyes with PXFS exhibited significantly thinner LCT than controls across all regions: superior mid-peripheral (163.85 ± 39.13 μm vs. 222.18 ± 38.03 μm, P < .001), central (172.95 ± 40.63 μm vs. 220.17 ± 51.77 μm, P < .001), and inferior mid-peripheral (165.58 ± 35.18 μm vs. 217.73 ± 44.00 μm, P < .001). No significant differences were observed in PLTT, LCCD and LCCI between the two groups. Multivariable mixed effects model analysis identified the presence of PXFS (β = -50.687, P < .001) as an independent factor associated with LCT.
Conclusion: PXFS eyes show significant LC thinning, potentially representing early structural changes preceding glaucoma. Monitoring LC parameters in PXFS eyes may facilitate early detection of patients at risk of disease progression.
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| http://dx.doi.org/10.1016/j.ajo.2025.02.041 | DOI Listing |
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