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Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome.
Sci Adv
March 2025
Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @UniTn, Rovereto, Italy.
Chromosome 22q11.2 deletion increases the risk of neuropsychiatric disorders like autism and schizophrenia. Disruption of large-scale functional connectivity in 22q11 deletion syndrome (22q11DS) has been widely reported, but the biological factors driving these changes remain unclear.
View Article and Find Full Text PDFResearch and analysis of differential gene expression in CD34 hematopoietic stem cells in myelodysplastic syndromes.
PLoS One
March 2025
Department of Hematology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi Medical College, Changzhi, Shanxi, China.
Objective: This study aims to investigate and analyze the differentially expressed genes (DEGs) in CD34 + hematopoietic stem cells (HSCs) from patients with myelodysplastic syndromes (MDS) through bioinformatics analysis, with the ultimate goal of uncovering the potential molecular mechanisms underlying pathogenesis of MDS. The findings of this study are expected to provide novel insights into clinical treatment strategies for MDS.
Methods: Initially, we downloaded three datasets, GSE81173, GSE4619, and GSE58831, from the public Gene Expression Omnibus (GEO) database as our training sets, and selected the GSE19429 dataset as the validation set.
BackMix: Regularizing Open Set Recognition by Removing Underlying Fore-Background Priors.
IEEE Trans Pattern Anal Mach Intell
March 2025
Open set recognition (OSR) requires models to classify known samples while detecting unknown samples for real-world applications. Existing studies show impressive progress using unknown samples from auxiliary datasets to regularize OSR models, but they have proved to be sensitive to selecting such known outliers. In this paper, we discuss the aforementioned problem from a new perspective: Can we regularize OSR models without elaborately selecting auxiliary known outliers? We first empirically and theoretically explore the role of foregrounds and backgrounds in open set recognition and disclose that: 1) backgrounds that correlate with foregrounds would mislead the model and cause failures when encounters 'partially' known images; 2) Backgrounds unrelated to foregrounds can serve as auxiliary known outliers and provide regularization via global average pooling.
View Article and Find Full Text PDFSCN3B is an Anti-breast Cancer Molecule with Migration Inhibition Effect.
Biochem Genet
March 2025
Department of Gynecology, People's Hospital of Jianshi, Enshi Tujia and Miao Autonomous Prefecture, Enshi City, Hubei Province, China.
Breast cancer is a prevalent and highly heterogeneous malignancy that continues to be a major global health concern. Voltage-gated sodium channels are primarily known for their role in neuronal excitability, but emerging evidence suggests their involvement in the pathogenesis of various cancers, including breast cancer. However, the effect of β-subunits on breast cancer cells is not yet studied.
View Article and Find Full Text PDFInvestigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson's disease.
Metab Brain Dis
March 2025
Xinxiang Key Laboratory of Targeted Intervention for Brain Cell Injury, Sanquan College of Xinxiang Medical University, Xinxiang, 453000, China.
Parkinson's disease (PD) is a chronic neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons, resulting in a range of disabling motor and non-motor symptoms. Despite advances, the molecular mechanisms underlying PD remain elusive, and effective biomarkers and therapeutic targets are limited. Recent studies suggest that mitochondrial dysfunction and dysregulated cellular metabolism are central to PD pathogenesis.
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