Acute pancreatitis manifests as an inflammatory condition, starting with the acinar cells in the pancreas and gradually escalating to widespread inflammation. Hypertriglyceridemia ranks as the third leading reason for acute pancreatitis, following gallstones and alcohol use, making up 2-14% of instances [1]. Numerous research findings indicate that acute pancreatitis triggered by hypertriglyceridemia (HTG-AP, hypertriglyceridemic acute pancreatitis) may lead to increased death rates compared to other acute pancreatitis causes hypertriglyceridemia, characterized by fasting serum triglycerides exceeding (150mg/dL; 1.7mmol/L), and severe hypertriglyceridemia, identified by levels above (885 mg/dL; > 10 mmol/L) [2]. This paper presents an uncommon instance of HTG-AP, triggered by polycystic ovary syndrome and treated with oral contraceptive Drospirenone and ethinylestradiol tablets, where serum triglyceride levels reached an unprecedented 9906.37 mg/dL.
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http://dx.doi.org/10.1007/s11739-025-03897-4 | DOI Listing |
Scand J Gastroenterol
March 2025
Department of Abdominal surgery, Helsinki University Hospital, Helsinki, Finland.
Objectives: Extracorporeal shock wave lithotripsy (ESWL) with endotherapy (ET) is the first-line treatment in patients with chronic pancreatitis (CP) and main pancreatic duct stone (PDS). Our study aimed to evaluate factors that predict the outcome of ESWL in CP patients with PDS.
Methods: We retrospectively analyzed data of 166 patients with CP and radiopaque PDS.
Nutrients
March 2025
Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Acute pancreatitis (AP) leads to severe inflammation and nutritional deficits, with 80% of severe cases experiencing critical protein loss. Timely enteral nutrition is essential for recovery. This study systematically reviews and analyzes the incidence and predictors of enteral nutrition intolerance (ENI) in AP patients.
View Article and Find Full Text PDFNutrients
February 2025
Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.
Background/objectives: Sarcopenia is a condition marked by a continuous decline in skeletal muscle strength and volume, often leading to significant health complications. According to several articles, sarcopenia is highly prevalent in chronic pancreatitis (CP) due to exocrine pancreatic insufficiency. The aim of this meta-analysis was to determine the pooled prevalence and risk of sarcopenia among CP patients.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Numerous animal experiments have implicated ferroptosis in the pathogenesis of acute pancreatitis (AP). Nonetheless, due to sampling constraints, the precise role of ferroptosis in the human body during AP remains elusive. Method: Peripheral blood sequencing data of patients with acute pancreatitis (GSE194331) were obtained from the Gene Expression Omnibus (GEO) database.
View Article and Find Full Text PDFAnimals (Basel)
February 2025
Nagaya Animal Medical Center, Nagoya 468-0024, Aichi, Japan.
Chronic enteropathy (CE) or chronic inflammatory enteropathy is a group of diseases with multiple and different etiologies characterized by chronic gastrointestinal signs such as vomiting, diarrhea, anorexia, weight loss for more than 3 weeks, and inflammatory cell infiltration, such as lymphoplasmacytic cells in the intestinal mucosal lamina propria. The diagnosis was histologically confirmed after excluding other diseases such as parasitic infections, tumors, pancreatitis, exocrine pancreatic insufficiency, metabolic diseases, and endocrine diseases, such as hypoadrenocorticism. Nutritional management depends on several important functions, such as digestion and absorption processes, digestive enzymes and nutritional transporters, and barrier functions.
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