Despite advancements in medicine, drug-induced liver injury continues to pose regulatory and clinical challenges. Ferulic acid, a naturally occurring polyphenol found in vegetables, fruits, and grains, has gained attention for its therapeutic properties. We report the hepatoprotective effects of ferulic acid against a range of pharmaceuticals and toxic compounds. Given the growing interest in natural hepatoprotective compounds, further research is essential to elucidate ferulic acid's role in liver protection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00204-025-03996-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Danshen-Chuanxiong-Honghua Ameliorates Neurological Function and Inflammation in Traumatic Brain injury in Rats via Modulating Ghrelin/GHSR.
J Ethnopharmacol
March 2025
Shenzhen Clinical College of Integrated Chinese and Western Medicine, Guangzhou University of Chinese Medicine; Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, P.R.China. Electronic address:
Ethnopharmacological Relevance: Guanxin II, proposed by Chen Keji (National master of traditional Chinese medicine), possesses cerebral-protective effect. Interestingly, its simplified prescription Danshen-Chuanxiong-Honghua (DCH) can also clinically ameliorate cerebral impairment and improve spatial cognitive deficits, similar to original formula's function.
Aim Of The Study: We aimed to elucidate the rationality of DCH's natural existence, qualitatively identify DCH-derived phytochemicals, thereby validate cerebral protective effect, and expose potential mechanism of DCH and its main absorbed compound ferulic acid (FA).
Non-covalent interaction of rice protein and polyphenols: The effects on their emulsions.
Food Chem
March 2025
State Key Laboratory of Food Science and Resources, Nanchang University, Jiangxi, Nanchang 330047, China; International Institute of Food Innovation, Nanchang University, Jiangxi, Nanchang 330200, China. Electronic address:
In this study, we investigated the non-covalent interaction mechanism between rice protein (RP) and three polyphenols with different concentrations (ferulic acid FA, gallic acid GA, and tannic acid TA) and their effects on the structure and emulsion stability of the proteins. Hydrophobic forces dominated the binding of RP to the polyphenols, and the reaction was heat-absorbing. The three polyphenols are bound to RP in the form of static quenching to form a non-covalent complex, and during the binding process, the RP provides one binding site.
View Article and Find Full Text PDFFire cupping inspired negative-pressure microneedle syringes loaded with herb berberine-based nano composite for psoriasis therapy.
Biomater Adv
March 2025
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330088, China; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, China. Electronic address:
Psoriasis, an immune-mediated chronic inflammatory skin disorder, poses challenges for topical treatment due to the thickening of the stratum corneum, hindering drug penetration. Furthermore, long-term use of chemical drugs may lead to immunosuppression and abnormal hepatic or renal dysfunction. Inspired by traditional Chinese fire cupping (Ba Huo Guan), a negative-pressure microneedle syringe therapy has been proposed here for psoriasis treatment.
View Article and Find Full Text PDFSurface moieties drive the superior protection of curcumin-derived carbon quantum dots against retinal ischemia-reperfusion injury.
J Mater Chem B
March 2025
Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan.
Despite the recognized neuroprotective benefits of curcumin, its clinical utility is constrained by poor bioavailability and high cytotoxicity at effective doses. This study evaluates the therapeutic potential of curcumin-derived carbon quantum dots (Cur-CQDs) for retinal protection against ischemia-reperfusion (IR) injury in rats. Cur-CQDs were synthesized mild pyrolysis at varying temperatures and assessed for efficacy in rat retinal ganglion cells and a model of retinal IR injury.
View Article and Find Full Text PDFComparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid.
Exp Dermatol
March 2025
Department of Animal Sciences, Plants for Human Health Institute, NC State University, Kannapolis, North Carolina, USA.
Cutaneous tissue is one of the main targets of outdoor stressors, and nowadays, the effect of pollution on skin conditions and premature skin ageing has been well correlated, although the exact effect that different pollutants have on the skin has not been well defined, especially when compared to other stressors. Among the air pollutants, UV radiation and particulate matter (PM) have been found among the most aggressive in terms of skin damage, inducing oxinflammatory responses, promoting degradation of extracellular matrix (ECM) components, and compromising the cutaneous defensive barrier. Topical application of technologies able to prevent oxidative damage is still one of the best approaches to protect our skin, and considering the well-known antioxidant network, application of an antioxidant mixture is more recommended than a single compound.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!