Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000410231 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ghost cells as a two-phase blood analog fluid: high-volume and high-concentration production.
Artif Organs
January 2025
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, University Hospital RWTH Aachen University, Aachen, Germany.
Background: Hemolysis in mechanical circulatory support systems is currently determined quantitatively. To also locally resolve hemolysis, we are developing a fluorescent hemolysis detection method. This requires a translucent two-phase blood analog fluid combined with particle image velocimetry, an optical flow field measurement.
View Article and Find Full Text PDFTangential flow filtration-facilitated purification of human red blood cell membrane fragments and its preferential use in removing unencapsulated material from resealed red blood cell ghosts compared to centrifugation.
Biotechnol Prog
December 2024
William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
The biodistribution of many therapeutics is controlled by the immune system. In addition, some molecules are cytotoxic when not encapsulated inside of larger cellular structures, such as hemoglobin (Hb) encapsulation inside of red blood cells (RBCs). To counter immune system recognition and cytotoxicity, drug delivery systems based on red blood cell membrane fragments (RBCMFs) have been proposed as a strategy for creating immunoprivileged therapeutics.
View Article and Find Full Text PDFCa-mediated reactive oxygen species signaling regulates cell repair after mechanical wounding in the red alga Griffithsia monilis.
J Phycol
August 2024
Department of Biological Sciences, Kongju National University, Gongju, Korea.
Article Synopsis
- When a cell gets damaged, it needs to heal quickly by sealing its membrane and fixing its insides to stay alive.* -
- In plant cells, this healing includes working on special parts like vacuoles and chloroplasts as well as fixing the cell wall.* -
- In a study, when a Griffithsia monilis cell was poked with a needle, it healed fast, showing that certain signals and structures in the cell helped with the repair process.*
Evaluation of Two Osmosis-Based Methods for the Preparation of Drug Delivery Systems Based on Red Blood Cells.
Pharmaceutics
September 2023
Area of Pharmacy and Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Salamanca, 37007 Salamanca, Spain.
Erythrocytes have been thoroughly investigated as drug delivery systems for a wide range of therapeutic molecules and using different kinds of loading methods, outstanding the osmosis-based methods as the most used ones. Most of them involve too much handling of blood components and the immediate obtention of fresh blood. Based on our group's considerable experience in dialysis-based carrier erythrocyte preparation, this study details a simple method based on hypotonic dilution and subsequent resealing that has been developed for stavudine using packed erythrocytes from a local blood bank.
View Article and Find Full Text PDFSorafenib Loaded Resealed Erythrocytes for the Treatment of Hepatocellular Carcinoma.
Recent Adv Drug Deliv Formul
July 2023
Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, 400 056, Maharashtra, India.
Background: This study aims to formulate and characterize sorafenib-loaded resealed erythrocytes (SoRE) and investigate their anticancer activity in a rat model of hepatocellular carcinoma.
Methods: SoRE were prepared by hypotonic dialysis of red blood cells obtained from Wistar rats using a range of drug-containing dialysis mediums (2-10 mg/ml) and osmosis time (30-240 mins). Optimized SoRE (8 mg/mL and 240 mins) were characterized for size, morphology, stability, entrapment efficiency, release profiles, and in vivo efficacy evaluations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!