Helical Sense Control of Metal-Peptide Torus Frameworks Leading to the Folding and Assembly of a AgL Braided Peptide Nanotube.

J Am Chem Soc

Laboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan.

Published: March 2025

The chirality of helical polypeptides is correlated to that of their constituent amino acid residues. For polypeptides with non-natural backbones, however, such correlations are less clear. Here, circular double helices with torus knot/link topologies were assembled from non-natural metal-peptide chains composed of Ag(I) ions and ditopic tripeptides with Gly-Gly-Ala and Gly-Ala-Gly sequences. We found that the chirality of the assembled helical structures is determined by the l-Ala's dihedral angles. A tubular dimeric structure with an ML composition was further achieved via additional metal cross-linking, showing rational design potential for artificial peptide helices.

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http://dx.doi.org/10.1021/jacs.5c01458DOI Listing

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