Objectives: Peer review typically relies on experts volunteering their time to review research. This process presents challenges for journals that may face a shortage of qualified referees, resulting in either delay in handling papers or less thorough review than is optimal. We experimentally tested the impact of providing cash incentives to complete peer review assignments at Critical Care Medicine.
Design: Quasi-randomized, blinded, interventional study with an alternating treatment design.
Setting: Critical Care Medicine (CCM), a peer-reviewed specialty journal.
Subjects: All reviewers receiving requests from CCM to review research articles during a 6-month period from September 2023 to March 2024 (excluding a 2-wk holiday window).
Interventions: In alternating 2-week blocks, reviewer invitation letters were sent out, including either an offer of $250 for accepting the peer review request (treatment) or the standard letter with no cash offer (control). Reviewers who fulfilled incentivized invitations received a $250 check from the journal.
Measurements And Main Results: Our primary outcome was the rate of invitation-to-completed-review conversion, defined as the number of reviews submitted divided by the number of reviewer invitations sent out. Secondary outcomes included the "on-time" conversion rate, invitation acceptance rate, time to invitation acceptance, time to review submission, and review quality. Seven hundred fifteen reviewer invitations were sent out, 414 of which (57.9%) included an incentive offer. Two hundred eighteen (52.7%) of the incentivized invitations were accepted, compared with 144 (47.8%) in the control group. A greater proportion of reviewer invitations led to submitted peer review reports in the incentive group than in the control group (49.8% [206/414] vs. 42.2% [127/301]; p = 0.04). In a "survival analysis," invitations sent with an incentive offer were fulfilled faster on average (Cox proportional hazard ratio, 1.30 [1.04-1.62]; p = 0.02), corresponding to quicker review times of approximately 1 day (11 vs. 12 d). Of the 333 reviewer reports submitted, 205 (61.6%) were assessed by editors, with no difference in review quality noted between study arms.
Conclusions: Providing cash incentive for completing peer review reports resulted in a modest increase in the share of invited reviewers who complete reviews for a specialty medical journal.
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http://dx.doi.org/10.1097/CCM.0000000000006637 | DOI Listing |
Int Ophthalmol
March 2025
Burapha University Hospital, Burapha University, Saen Suk, Chonburi, Thailand.
Background: Retinitis pigmentosa (RP) is a retinal dystrophy and genetically heterogeneous group that causes vision loss and necessitates innovative therapeutic strategies, and mesenchymal stem cell (MSC) therapy has shown potential due to its regenerative and immunomodulatory properties. This meta-analysis aims to evaluate the efficacy and safety of MSC therapies in improving visual outcomes, focusing on the impact of various MSC types, administration methods, and duration of benefits.
Methods: A systematic search of peer-reviewed studies was conducted to identify clinical trials and observational studies investigating MSC therapies for retinal conditions.
Drugs
March 2025
Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.
Revumenib (Revuforj) is an oral, first-in-class menin inhibitor developed by Syndax Pharmaceuticals for the treatment of KMT2A-rearranged (KMT2Ar) acute leukaemia, NPM1-mutated (NPM1m) acute myeloid leukaemia (AML) and solid tumours. The interaction between menin and the KMT2A protein complex leads to aberrant gene expression, driving leukaemogenic transcription. By blocking this interaction, revumenib promotes differentiation and exerts antileukaemic activity in KMT2Ar acute leukaemias and other menin inhibition-sensitive leukaemias.
View Article and Find Full Text PDFDrug Saf
March 2025
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Introduction: Most epidemiological studies have found antibiotics to be the most common cause of drug-induced liver injury (DILI). It is unclear what the risk of DILI is associated with different antibiotics.
Objective: The aim of the study was to assess the frequency of DILI due to the most commonly used antibiotics among inpatients, in a population-based setting.
Radiol Artif Intell
March 2025
Department of Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, Calif.
Retrieval-augmented generation (RAG) is a strategy to improve performance of large language models (LLMs) by providing the LLM with an updated corpus of knowledge that can be used for answer generation in real-time. RAG may improve LLM performance and clinical applicability in radiology by providing citable, up-to-date information without requiring model fine-tuning. In this retrospective study, a radiology-specific RAG was developed using a vector database of 3,689 articles published from January 1999 to December 2023.
View Article and Find Full Text PDFRadiol Artif Intell
March 2025
Department of Radiology, Duke University Hospital, 2301 Erwin Rd, Durham, NC 27710.
Purpose To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights language models (LMs) and retrieval augmented generation (RAG) and to assess the effects of model configuration variables on extraction performance. Materials and Methods This retrospective study utilized two datasets: 7,294 radiology reports annotated for Brain Tumor Reporting and Data System (BT-RADS) scores and 2,154 pathology reports annotated for mutation status (January 2017 to July 2021). An automated pipeline was developed to benchmark the performance of various LMs and RAG configurations for structured data extraction accuracy from reports.
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