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http://dx.doi.org/10.3389/fnins.2025.1565790 | DOI Listing |
Arterioscler Thromb Vasc Biol
March 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm U1148-LVTS, France.
Front Mol Neurosci
February 2025
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, United States.
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal gene expression is observed in postmortem human brain and mouse models of DS/AD. To date, RNA-sequencing (RNA-seq) analysis of hippocampal neuronal gene expression including the characterization of discrete circuit-based connectivity in DS remains a major knowledge gap.
View Article and Find Full Text PDFFront Pharmacol
February 2025
James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, United States.
Purpose: Vancomycin is an essential antibiotic for the treatment of severe gram-positive bacterial infections, including methicillin-resistant (MRSA). In critically ill patients, particularly children, attaining the appropriate dosage is crucial to avert drug resistance and ensure therapeutic efficacy. This study sought to investigate the pharmacokinetics of vancomycin in critically ill Asian pediatric patients and evaluate the influence of extracorporeal membrane oxygenation (ECMO) and disease severity on vancomycin clearance.
View Article and Find Full Text PDFFront Pharmacol
February 2025
Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, Defense Health Agency Research and Development, Medical Research and Development Command, Frederick, MD, United States.
Transporters are membrane proteins that are critical for normal cellular function and mediate the transport of endogenous and exogenous chemicals. Chemical interactions with these transporters have the potential to affect the pharmacokinetic properties of drugs. Inhibition of transporters can cause adverse drug-drug interactions and toxicity, whereas if a drug is a substrate of a transporter, it could lead to reduced therapeutic effects.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Organic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
The considerable health risks associated with fungal infections are continuously rising, thereby requiring proper and efficient antifungal treatment options [...
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