Background: The Global Leaders Group on Antimicrobial Resistance (AMR) beckoned nations to share surveillance data on antimicrobial consumption (AMC) and AMR while promoting access to essential antimicrobials in countries with the highest burden of AMR.
Objectives: To analyse findings of the national-level AMC (years 2020-2022), building on our prior work (2017-2019), and to assess any emerging trends.
Methods: Data were obtained from the Tanzania Medicines and Medical Devices Authority, Tanzania Medical Stores Department, and from local manufacturers.
Results: The average defined daily dose (DDD) per 1000 inhabitants (DID) was 38.27 ± 5.17. Compared to 2020, macrolides had a nearly 3-fold increase in 2021 and 2022 driven by azithromycin (4.85 ± 2.85 DID), mainly associated with inappropriate use during the COVID-19 pandemic. In 2020, private-sector consumption accounted for 75.73% of the total, which increased to 84.02% in 2021 and then slightly decreased to 66.82% in 2022. The Access category antimicrobials met the World Health Organization target of 60% national consumption, while the Watch category has shown a steady increase in 2021 and 2022.
Conclusion: The continued increase in AMC in the private sector calls for urgent antimicrobial stewardship targets, including routine reporting by the Access, Watch and Reserve categories.
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http://dx.doi.org/10.1093/jacamr/dlaf026 | DOI Listing |
Biometrics
January 2025
Vanke School of Public Health, Tsinghua University, Beijing, 100084, China.
The segmented model has significant applications in scientific research when the change-point effect exists. In this article, we propose a comprehensive semiparametric framework in segmented models to test the existence and estimate the location of change points in the generalized outcome setting. The proposed framework is based on a semismooth estimating equation for the change-point estimation and an average score-type test for hypothesis testing.
View Article and Find Full Text PDFInt J Surg
March 2025
Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: Previous studies have reported the effectiveness of the "enhanced recovery after surgery" program in patients who underwent gastric cancer surgery, mostly based on the 2014 gastrectomy guidelines. Therefore, based on subsequent advancements in perioperative management, this randomized, controlled, open-label, single-center study aimed to assess the impact of a recent evidence-based multimodal enhanced recovery after surgery program on the quality of early recovery after gastric cancer surgery.
Materials And Methods: This study included adult patients scheduled to undergo elective laparoscopic or robotic distal gastrectomy for gastric cancer.
Nanomaterials (Basel)
February 2025
Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.
Sn-doped TiO-carbon composites were identified as promising multifunctional supports for Pt electrocatalysts, in which the oxide component enhances resistance against corrosion and strong metal-support interactions at the Pt-oxide boundary ensure high stability for the Pt nanoparticles. This work is devoted to the study of the influence of preliminary functionalization of the carbon on the properties of Pt/TiSnO-C catalysts. The structural, compositional and morphological differences between the samples prepared using functionalized or unmodified carbon, as well as the effect of carbon pre-modification on the electrocatalytic behavior of the synthesized Pt catalysts, were investigated using TEM, XRD, XPS, nitrogen adsorption and electrochemical measurements.
View Article and Find Full Text PDFWomens Health (Lond)
March 2025
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Background: Retention of weight postpartum increases risk for long-term morbidity, including cardiometabolic disease. Although retained weight postpartum is a complex problem, interventions generally address individual diet and activity behaviors.
Objectives: We investigated the impact of social-network factors on postpartum health behaviors and weight.
J Clin Microbiol
March 2025
Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
serotype 23B, a non-vaccine serotype, has shown an increasing prevalence and penicillin non-susceptibility among carriage and invasive pneumococcal disease (IPD) isolates. Recently, a novel penicillin non-susceptible genotype has emerged, named 23B1. In the framework of the Belgian pneumococcal carriage study, we studied the prevalence of 23B/23B1 among 586 23B strains (2016-2022) in 172 day care centers from 6- to 30-month-old children and among 130 pediatric 23B IPD isolates (2007-2021).
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