To address the underreporting of mpox cases in endemic regions, a regional surveillance network, known as the Mpox Threat Reduction Network (MPX-TRN), was established between five neighboring countries in Central and West Africa in 2022. One direct outcome of the MPX-TRN has been the strengthening of regional mpox surveillance. This consortium has facilited open communication channels, detection of cross-border mpox cases, and improvements of the detection and diagnosis of mpox in Central Africa and worldwide. Importantly, the MPX-TRN provides a scalable model for addressing underreporting of diseases, such as mpox.
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http://dx.doi.org/10.1186/s41256-025-00408-y | DOI Listing |
J Med Microbiol
March 2025
NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, UK.
The management of patients with acute infectious diseases can present significant challenges, especially if the causative agent has a propensity for person-to-person transmission. In such cases, effective patient management is dependent on both rapid identification of disease and the provision of necessary medical care while adhering to suitable infection prevention and control measures to reduce the potential for onwards transmission. The UK has operated a defined system for managing patients with high-consequence infectious diseases (HCIDs) since the 1970s, when protocols were first implemented following the first descriptions of several viral haemorrhagic fever diseases, including Marburg virus disease, Lassa fever and Ebola virus disease (EVD).
View Article and Find Full Text PDFFront Med (Lausanne)
February 2025
Department of Dermatology, College of Health Sciences and Medicine, Bahir Dar University, Bahir Dar, Ethiopia.
Introduction: Mpox is a viral disease that primarily affects individuals living in endemic regions. The 2022 outbreak notably impacted HIV-positive individuals, who were disproportionately affected. This report describes the first confirmed case of Mpox in Burundi, involving an HIV-positive patient with advanced disease.
View Article and Find Full Text PDFPLoS One
March 2025
Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.
Background: Ontario, being one of Canada's largest provinces, has been central to the high incidence of human Mpox. Research is scarce on how socio-environmental factors influence Mpox incidences. This study seeks to explore potential geographical correlations and the relationship between indicators of social marginalization and Mpox incidence rate in Ontario.
View Article and Find Full Text PDFInfect Med (Beijing)
March 2025
Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, India.
Mpox, formerly known as monkeypox, is a zoonotic virus of the genus, with recent outbreaks of Clade I and Ib in Central Africa presenting a considerable global health threat. This study reviews current Mpox immunization approaches, focusing on the MVA-BN, LC16-KMB, and OrthopoxVac vaccines. MVA-BN vaccination has been successful in lowering infection risks, particularly in high-risk individuals and is widely used in the USA.
View Article and Find Full Text PDFNurs Stand
March 2025
Gay Men's Health Service, Health Service Executive, Dublin, Republic of Ireland.
Mpox, previously known as monkeypox, is a viral disease that has become a significant global health concern following outbreaks beyond its endemic regions in central and west Africa. In 2022, the World Health Organization declared a 'public health emergency of international concern' (PHEIC) due to a rise in mpox cases, predominantly affecting gay and bisexual men. Although the initial surge of cases had diminished by early 2023, a new PHEIC was declared in 2024 due to a more severe strain of the virus circulating in the Democratic Republic of the Congo.
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