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http://dx.doi.org/10.1186/s13045-025-01682-6 | DOI Listing |
J Hematol Oncol
March 2025
Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.
Adv Sci (Weinh)
February 2025
Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia-(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown. Herein, it is shown that MAD patients achieved inflammaging with different pro-inflammatory cytokines compared to progeria-(HGPS) patient.
View Article and Find Full Text PDFScand J Immunol
December 2024
Department of Pediatrics, Institute of Health Sciences, Division of Pediatric Immunology and Allergy and Master's/Doctoral Program, Jeffrey Modell Primary Immunodeficiency Diagnosis Center, Işıl Barlan Translational Medicine Center, Immunodeficiency Application and Research Center, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Clin Exp Immunol
January 2025
Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
The American tegumentary leishmaniasis (ATL) is caused by protozoans of the genus Leishmania and varies from mild localized cutaneous leishmaniasis (LCL) form to more severe manifestations such as the diffuse cutaneous leishmaniasis (DCL) form and the mucosal leishmaniasis (ML) form. Previously, we demonstrated the accumulation of senescent cells in skin lesions of patients with LCL. Moreover, lesional transcriptomic analyses revealed a robust co-induction of senescence and pro-inflammatory gene signatures, highlighting the critical role of senescent T cells in orchestrating pathology.
View Article and Find Full Text PDFFront Public Health
May 2024
Pan American Health Organization, Washington, DC, United States.
[This corrects the article DOI: 10.3389/fpubh.2024.
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