Background: Chronic respiratory diseases (CRDs) are the third leading cause of death worldwide. Data of the associations between specific volatile organic compounds (VOCs), a major component of air pollution and tobacco smoke, and subsequent CRD mortality in the general population are scarce.
Methods: In a case-cohort analysis within the population-based Golestan cohort study (n = 50045, aged 40-75 years, 58% women, enrollment: 2004-2008, northeastern Iran), we included all participants who died from CRD during follow-up through 2018 (n = 242) as cases and stratified them into 16 strata defined by age, sex, residence, and tobacco smoking. Subcohort participants (n = 610) were randomly selected from all eligible cohort participants in each stratum, and sampling fractions were calculated. Baseline urine samples were used to measure 20 VOCs using ultra high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. After excluding participants with previous history of CRDs, we used stratified Cox regression models weighted by the inverse sampling fractions (i.e. inverse probability weighting) adjusted for potential confounders, including urinary cotinine and pack-years of smoking, to calculate hazard ratios (HR) for the associations between biomarker tertiles and CRD mortality.
Results: Data from 545 non-case, sub-cohort participants and 149 cases (69.1% chronic obstructive pulmonary disease, 13.4% asthma, 17.5% other CRDs) were assessed in this study. During a follow-up of 10.5 years, associations [2nd and 3rd vs. 1st tertiles, HR (95% confidence interval), p for trend] were observed between metabolites of acrolein [1.56 (0.64,3.79), 3.53 (1.53,8.16), 0.002] and styrene/ethylbenzene [1.17 (0.53,2.60), 3.24 (1.37,7.66), 0.005] and CRD mortality, which persisted after excluding the first four years of follow-up.
Conclusion: Our findings support prior research suggesting respiratory toxicity of VOCs. Further investigation and monitoring of these compounds, especially acrolein and styrene/ethylbenzene, as CRD risk factors, are recommended.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884121 | PMC |
| http://dx.doi.org/10.1186/s12931-025-03165-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.
Anal Chim Acta
May 2025
Department of Human Sciences, The Ohio State University, USA; James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:
Background: The imperative need for early cancer detection, which is crucial for improved survival rates in many severe cancers such as lung cancer, remains challenging due to the lack of reliable early-diagnosis technologies and robust biomarkers. To address this gap, innovative screening platforms are essential to unveil the chemical signatures of lung cancer and its treatments. It is established that the oxidative tumor environment induces alterations in host metabolic processes and influences endogenous volatile synthesis.
View Article and Find Full Text PDFFacile preparation of lac terpene acid based heat setting adhesive with improved performances.
Int J Biol Macromol
March 2025
Institute of Highland Forest Science, Chinese Academy of Forestry, Research Center of Engineering and Technology of Characteristic Forest Resources, Key Laboratory of Breeding and Utilization of Resource Insects, National Forestry and Grassland Administration, Kunming 650233, China. Electronic address:
As a by-product of shellac resin, the high-value utilization of lac terpene acid (LTA) is a major challenge. In this study, a novel adhesive material, designated as A-LTA, was developed through a facile synthesis reaction between LTA and melamine, demonstrating significantly enhanced performance characteristics. The A-LTA adhesive, owing to its diverse functional groups, demonstrates exceptional cross-linking and polymerization capabilities under elevated temperatures, resulting in the formation of multiple chemical bonds and a highly dense network structure.
View Article and Find Full Text PDFDiurnal variations of biogenic volatile organic compounds and their role in secondary pollutant formation in the Huai Hong Khrai subtropical forest, Thailand.
Environ Pollut
March 2025
National Astronomical Research Institute of Thailand (Public Organization), Chiang Mai, Thailand; School of Science, Mae Fah Luang University, Chiang Rai, Thailand; Center of Chemical Innovation for Sustainability (CIS), Mae Fah Luang University, Chiang Rai, Thailand. Electronic address:
Understanding the emissions and atmospheric impact of biogenic volatile organic compounds (BVOCs) in subtropical forests remains limited despite their role in secondary pollutant formation. This study presents the first comprehensive BVOC dataset from the Huai Hong Khrai subtropical forest, Northern Thailand, during the dry season (March 4-9, 2024). Using thermal desorption gas chromatography-mass spectrometry (TD-GC-MS), we identified 45 BVOCs, dominated by monoterpenes, sesquiterpenes, and oxygenated derivatives.
View Article and Find Full Text PDFCo-decoding dynamics in volatiles and sensory profiles of Zhaiji millet vinegar during aging by integrating multiple flavor characterization techniques and chemometrics.
Food Chem
March 2025
College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China. Electronic address:
Zhaiji millet vinegar (ZJMV) is a signature acidic condiment. To investigate the effect of aging on the flavor of ZJMV, here gas chromatography-mass spectrometry (GC-MS), gas chromatography-ion mobility spectrometry (GC-IMS), electronic nose, electronic tongue, and quantitative descriptive analysis were used to characterize the flavor profiles of ZJMV for five aging years (2 to 10 years). GS-MS and GC-IMS identified 84 and 44 volatile organic compounds (VOCs), with the most abundant alcohols and esters (p < 0.
View Article and Find Full Text PDFSupplementation of a Basal Goat Diet With Incremental Doses of Canola Essential Oil Modulates In Vitro Rumen Fermentation and Microbial Diversity.
Vet Med Sci
March 2025
Department of Animal Science, Faculty of Natural and Agricultural Science, North-West University, Mmabatho, South Africa.
Background: Canola essential oil (CEO) contains linoleic and oleic fatty acids that can inhibit the growth of pathogenic micro-organisms and alter microbial digestion to increase ruminal fermentation and nutrient utilisation.
Objectives: The study evaluated the effect of supplementing a basal goat diet with incremental doses of CEO on chemical constituents and in vitro ruminal fermentation parameters and microbial diversity.
Methods: Experimental treatments were a basal goat diet containing 0.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!