Objectives: To examine the amount of residual monomer released from adhesive-precoated flash-free brackets and compare it to traditional light cure and chemical cure adhesives.
Materials And Methods: Sixty stainless steel brackets were bonded on upper premolar teeth using three groups of adhesive systems: Adhesive-precoated flash-free system, Transbond XT light cure, Sia chemical cure. The extracts of 0.5 ml of liquid samples were taken on the first, 7th, 21st, and 35th days. To determine the amount of residual monomer release, extracted samples were analyzed using a liquid chromatography device.
Results: Urethane-dimethacrylate, triethylene glycol dimethacrylate, hydroxyethyl methacrylate and Bisphenol A-glycidyl methacrylate monomers were released from all study groups. The amount of total monomer release except hydroxyethyl methacrylate was detected as greater in adhesive-precoated flash-free system. Among the study groups, the chemical cure group showed the highest hydroxyethyl methacrylate monomer release.
Conclusions: This in vitro study indicate that the APC flashless system exhibited the greatest release of residual monomers, suggesting that its possible cytotoxic effects need to be evaluated prior to clinical application.
Clinical Relevance: This is the first study that evaluates the residual monomer release from adhesive-precoated flash-free brackets. The novel bracket system has a different mesh structure at the bracket base compared to traditional systems with different chemical components which might alter the amount of residual monomer release. To investigate the harmful effects of adhesives used in orthodontic applications is very important for the health of the patient and the orthodontist.
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http://dx.doi.org/10.1007/s00784-025-06250-3 | DOI Listing |
Eur J Pharm Sci
March 2025
Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany; Halle Research Centre for Drug Therapy (HRCDT), Halle (Saale), Germany. Electronic address:
Poly(lactic-co-glycolic acid) (PLGA) is a prominent biodegradable polymer used in biomedical applications, including drug delivery systems (DDS) and tissue engineering. PLGA's ability to control drug release is often hindered by nonlinear release profiles and slow initial drug release for hydrophobic drugs. This study investigates the incorporation of dexamethasone phosphate (DEXP) into polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) implants to enhance the initial release rate of dexamethasone (DEX).
View Article and Find Full Text PDFChemSusChem
March 2025
Aristotle University of Thessaloniki, of Chemistry, University Campus, Laboratory of Organic Chemical Technology, 541 24, Thessaloniki, GREECE.
This research explores the potential exploitation of recycled PET bottles in developing dimethacrylated oligoesters to be used as alternative monomers to produce novel dimethacrylate-based dental resins. Specifically, oligoester diols derived from PET glycolysis were converted into dimethacrylated oligoesters (PET-GLY-DMs), as alternative monomers to Bisphenol-A glycidyl methacrylate (Bis-GMA). The glycolysis products were analyzed for their molecular weight using GPC and the successful conversion of hydroxyl to methacrylate groups via methacrylation was confirmed by FT-IR spectroscopy.
View Article and Find Full Text PDFJ Pharm Bioallied Sci
December 2024
Department of Prosthodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India.
Background And Objective: Inspite of advancements in material properties of heat cure acrylic resin, fracture of denture base and allergic reactions due to release of residual monomer is encountered frequently. To improve strength and to reduce residual monomer, different polymerization methods need to be investigated. The objective is to evaluate and compare transverse strength and residual monomer content of two different heat cured denture base resins polymerized by conventional water bath and by autoclave.
View Article and Find Full Text PDFBiochemistry (Mosc)
January 2025
Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002, Russia.
Supraphysiological concentrations of calciprotein particles (CPPs), which are indispensable scavengers of excessive Ca and PO ions in blood, induce pro-inflammatory activation of endothelial cells (ECs) and monocytes. Here, we determined physiological levels of CPPs (10 μg/mL calcium, corresponding to 10% increase in Ca in the serum or medium) and investigated whether the pathological effects of calcium stress depend on the calcium delivery form, such as Ca ions, albumin- or fetuin-centric calciprotein monomers (CPM-A/CPM-F), and albumin- or fetuin-centric CPPs (CPP-A/CPP-F). The treatment with CPP-A or CPP-F upregulated transcription of pro-inflammatory genes (, , , , , , , ) and promoted release of pro-inflammatory cytokines (IL-6, IL-8, MCP-1/CCL2, and MIP-3α/CCL20) and pro- and anti-thrombotic molecules (PAI-1 and uPAR) in human arterial ECs and monocytes, although these results depended on the type of cell and calcium-containing particles.
View Article and Find Full Text PDFAnal Chim Acta
April 2025
Key Laboratory of Beijing on Regional Air Pollution Control, Department of Environmental Science, Beijing University of Technology, Beijing, 100124, PR China.
Liquid crystal monomers (LCMs) are a class of emerging organic pollutants widely used in liquid crystal displays (LCDs) of various electronic products. LCMs can easily be released from LCDs into indoor environments and may pose potential environmental and health risks. Meanwhile, LCMs exhibit a wide range of saturation vapor pressures (PL) and octanol-air partition coefficients (Koa), which enable their presence in various indoor metrices.
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