Fibrillated Tau proteins are believed to be a signature of Alzheimer's disease (AD) and may be potentially employed as a biosensor for AD early detection. Several studies revealed the presence of Tau accumulation and aggregation in the retina, similar to that observed in the brains of individuals with AD. These retinal changes can be non-invasively visualised through AD-related scores derived from reflectance measurements of the patient fundus. However, a direct link with the optical properties of fibrillated protein clusters is still lacking. Here, we present a new optical technique which measures the scattering optical properties of protein fibrils. Our experimental findings show that the scattering intensity of Tau has a wavelength dependence correlated to their size. The optical signal qualitatively replicates the spectral signature observed in human AD patient retinas. Our paper shows that the Tau protein spectral signature is compatible with the distinctive spectral signature of the AD, further confirming that retinal investigation is a promising tool.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882907 | PMC |
| http://dx.doi.org/10.1038/s41598-025-92565-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Decoding Double Layer Dynamics for CO2 Electroreduction over Cu.
Angew Chem Int Ed Engl
March 2025
Technion Israel Institute of Technology, Schulich Faculty of Chemistry, Technion City, 320000, Haifa, ISRAEL.
Understanding of the nature and role of the electric double layer (EDL) at electrocatalytic interfaces is critical to optimizing electrochemical processes such as the carbon dioxide reduction reaction (CO2RR). Despite its postulated influence on CO2RR activity, direct spectroscopic evidence of the complex interplay between EDL structure and reaction kinetics remains elusive. Here, we introduce Dynamic Response Spectroscopy (DRS), a novel approach that isolates spectroscopic signatures of key physicochemical features of the EDL, including the compact (interfacial) layer and the diffuse double layer based on their time-variance profiles.
View Article and Find Full Text PDFPositive Ion Tandem Mass Spectrometry Offers Enhanced Structural Insights for the Discovery of Mercapturic Acids.
Chem Res Toxicol
March 2025
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Urinary mercapturic acids represent valuable biological markers of chemical exposure and detoxification mechanisms. Characterization of this class of compound has historically employed LC-MS/MS analytical platforms using negative ion mode. In this study, we report the first application of a UHPLC-MS/MS method using positive ion mode detection for the unbiased characterization of mercapturic acids.
View Article and Find Full Text PDFAchieving a high level of immersion and adaptation in virtual reality (VR) requires precise measurement and representation of user state. While extrinsic physical characteristics such as locomotion and pose can be accurately tracked in real-time, reliably capturing mental states is more challenging. Quantitative psychology allows considering more intrinsic features like emotion, attention, or cognitive load.
View Article and Find Full Text PDFMultiple proxies to investigate the submarine groundwater discharge into the Arabian Sea, Southwest coast, India: integration of biogeochemical, geophysical, and remote sensing techniques.
Environ Sci Pollut Res Int
March 2025
National Centre for Earth Science Studies, Ministry of Earth Sciences, Thiruvananthapuram, India, 695011.
Submarine Groundwater Discharge (SGD) constitutes a pivotal mechanism for the transference of freshwater, nutrients, and pollutants from terrestrial to marine environments, exerting a profound influence on coastal water quality and ecosystem dynamics. In this investigation, we executed an extensive field sampling campaign along the 650 km coastal expanse of southwest India, employing a 10-km sampling interval, to discern and validate the probable zones of SGD. We have utilized a transect-based methodology for the systematic collection of groundwater, porewater, and seawater samples, employing a suite of proxies to scrutinize SGD).
View Article and Find Full Text PDFCD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults.
Immun Ageing
March 2025
Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Background: The T cell compartment undergoes significant age-related changes, contributing to the decline of the adaptive immune system and increasing the risk of suboptimal antibody responses to vaccines in older adults. To better understand the association between T cell phenotypes and vaccine responsiveness, we conducted an in-depth analysis of CD4+, CD8+, and γδ + T cells on VITAL cohort participants who are low or high responders to multiple vaccines (influenza, pneumococcal, and SARS-CoV-2).
Results: Using spectral cytometry and FlowSOM, we identified detailed phenotypes of naïve, regulatory, and terminally differentiated T cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!