Plastic scintillators, segmented into small, optically isolated voxels, are used for detecting elementary particles and provide reliable particle identification with nanosecond time resolution. Building large detectors requires the production and precise alignment of millions of individual units, a process that is time-consuming, cost-intensive, and difficult to scale. Here, we introduce an additive manufacturing process chain capable of producing plastic-based scintillator detectors as a single, monolithic structure. Unlike previous manufacturing methods, this approach consolidates all production steps within one machine, creating a detector that integrates and precisely aligns its voxels into a unified structure. By combining fused deposition modeling with an injection process optimized for fabricating scintillation geometries, we produced an additively manufactured fine-granularity plastic scintillator detector with performance comparable to the state of the art, and demonstrated its capabilities for 3D tracking of elementary particles and energy-loss measurement. This work presents an efficient and economical production process for manufacturing plastic-based scintillator detectors, adaptable to various sizes and geometries.
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http://dx.doi.org/10.1038/s44172-025-00371-z | DOI Listing |
J Chem Phys
March 2025
Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
The nucleosome serves as the fundamental unit of chromatin organization, with electrostatic interactions acting as the driving forces in the folding of nucleosomes into chromatin. Perturbations around physiological pH conditions can lead to changes in the protonation states of titratable histone residues, impacting nucleosome surface electrostatic potentials and interactions. However, the effects of proton uptake or release of histone ionizable groups on nucleosome-partner protein interactions and higher-order chromatin structures remain largely unexplored.
View Article and Find Full Text PDFRadiology
March 2025
From the Department of Radiology, Brigham and Women's Hospital, Boston, Mass (F.R.S., A.D.S.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.); Department of Radiology, University of Washington Medicine, Seattle, Wash (D.V.S.); and Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.H.L., R.G.).
Photon-counting CT (PCCT) has emerged as a transformative technology, with the potential to herald a new era of clinical capabilities. This review provides an overview of the current status and potential future developments of PCCT, including basic physics principles and technical implementation by different vendors, with special attention to applications that have not, to date, been emphasized in the literature. The technologic underpinnings that distinguish PCCT scanners from traditional energy-integrating detector (EID) CT scanners with dual-energy capability are discussed.
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March 2025
Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Low-dose total skin electron beam therapy (TSEBT) is an effective treatment option for mycosis fungoides (MF) with proven palliative effects and reduced toxicity. Presented is an institutional analysis of survival/response rate and quality of life for MF patients with subgroup analysis of those possessing pathologic large cell transformation (LCT). This is a single institutional retrospective review of patients with mycosis fungicides treated from 2014 to 2023 with low-dose TSEBT.
View Article and Find Full Text PDFNat Commun
March 2025
Howard Hughes Medical Institute, University of California, Los Angeles, CA, 90095, USA.
High-resolution information is important for accurate structure modeling but is challenging to attain in macromolecular crystallography due to the rapid fading of diffracted intensities at increasing resolution. While direct electron detection essentially eliminates the read-out noise during MicroED data collection, other sources of noise remain and limit the measurement of faint high-resolution reflections. Inelastic scattering significantly contributes to noise, raising background levels and broadening diffraction peaks.
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