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Post-Bariatric Hypoglycemia After Gastric Bypass: Clinical Characteristics, Risk Factors, and Future Directions-A Response to Grover et al.
Clin Endocrinol (Oxf)
March 2025
Department of Addiction Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan City, Taiwan.
Background: Post-bariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB) is a complex complication, often characterized by potentially severe hypoglycemic episodes and reduced hypoglycemia awareness. Recent findings suggest that autonomic dysfunction, preoperative hypoglycemia symptoms, and early dumping syndrome may each contribute to PBH risk.
Objective: To discuss critical insights from the recent study by Grover et al.
Exploring the scope of inspiratory muscle training in difficult weaning: reflections on the multicentre RCT.
J Intensive Care
March 2025
Department of Anaesthesiology and Critical Care, AIIMS, Jodhpur, India.
We commend the authors for their insightful study on inspiratory muscle training (IMT) in mechanically ventilated patients with difficult weaning, highlighting the robust use of maximum inspiratory pressure (MIP) as a key outcome. We suggest that a lower baseline maximum inspiratory pressure cutoff could better target patients with significant inspiratory dysfunction, improving the study's precision. Additionally, alternative imputation techniques, such as multiple imputation, could strengthen the handling of missing data.
View Article and Find Full Text PDFA real-world experience of efficacy and safety of belantamab mafodotin in relapsed refractory multiple myeloma.
Blood Cancer J
March 2025
Department of Hematology-Oncology, Medical University of South Carolina, Charleston, SC, USA.
While initial trials led to the accelerated approval of belantamab mafodotin, a BCMA-directed antibody-drug conjugate, confirmatory trials failed to establish benefit from this therapy for patients with relapsed refractory multiple myeloma (RRMM), eventually leading to its withdrawal from commercial use. With an imminent approval as an effective combination therapy, as seen in recent randomized trials, we report real-world clinical outcomes with belantamab mafodotin in 81 RRMM patients. With a median of 5 (range 2-15) prior lines of therapy, 92, 45, and 15% of the patients were triple-class refractory, penta-class refractory, and BCMA-refractory.
View Article and Find Full Text PDFThe liminal space of metacognitive reflection: the art of contradistinction (a response to define or not define).
Adv Health Sci Educ Theory Pract
March 2025
HU University of Applied Sciences Utrecht, Utrecht, Netherlands.
In this commentary, the authors respond to Ellaway & Patocka's "To define or not to define: A commentary on the Case for Metacognitive Reflection," which raised several thoughtful and discerning questions concerning the implications of defining, or alternatively, refraining from defining constructs. The authors advocate for navigating the liminal space between precision and flexibility, acknowledging the dynamic and permeable nature of conceptual boundaries while striving for clarity. Moreover, they emphasize that only after a boundary is described can the tensions, gaps, exceptions, and contradictions around that boundary be explored.
View Article and Find Full Text PDFThe short comment on the individual response to ionizing radiation.
J Theor Biol
March 2025
Faculty of Physics, Warsaw University of Technology (WF PW), Poland. Electronic address:
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